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Mechanism Study and Drug Development for Metabolic Disorders, such as non-alcoholic fatty liver diseases, Diabetes and Atherosclerosis

Innovative drug discovery and personalized research focused on proteostasis.

1. Humanized Mice Disease Models.

2. Humanized Drug Targets.

3. RNA and Protein Drugs.

1. Chemical synthesis of bioactive and complex glycoside and glycans

2. Development of novel and efficient methodology to access glycans

3. Structure bioactivity relationship studies on the bioactive carbohydrate-based compound

1.Development of new radiopharmaceutical

2.Development of new molecular imaging tools for CNS diseases

Prof. Yang's research interests focus on new drug discovery and development, spanning anti-infectives, anticoagulants, anticancer drugs and central nervous system drugs.

1. Medicinal Chemistry: Hit generation and lead optimization based on the new synthetic method. Design and synthesis of "medicinal lead compounds" with both biological activity and medicinal properties for clinical needs such as tumors and metabolic diseases.

2. Organic Chemistry: Development of useful new synthetic reactions and asymmetric catalysis strategy for rapidly construction of structurally diversified compounds with potential medicinal skeleton.

1. Immunoneuropsychiatry

2. Development of biopharmaceuticals for CNS disorders