全国同城凤凰楼信息茶楼_51pcmc品茶2024官网_全国兼职凤凰楼信息

Pharmacology、Pathology、Proteomics、Metabonomics、Immunology、Cardiovascular system

1. Research on the Structure and function of hormone receptors;

2. Research on the biased signaling of G protein-coupled receptors (GPCRs) and biased drug discovery;

3. Research on the signaling transduction of chemosensors.

Innovative drug discovery and evaluation; Drug mechanism of action and new target; Chemicobiology in cell recognition and cell fate regulation

Carbohydrates play important roles in biological systems and influence cancer metastasis, bacterial and viral infection, cell-cell interactions. We focus on glycobiology, glycochemistry, medicinal chemistry and chemical biology, with emphasis on automated synthesis, carbohydrate-based vaccines, glycopeptide and glycoprotein drugs.

Study on Disease Treatment Strategies based on proteomics

Dr. Kan Ding’s research interest mainly focuses on the structure and function, structure-activity relationship, targeting molecular discovery and action mechanism of polysaccharides from traditional Chinese medicine, relationship between bioactive polysaccharide and gut microbiota, and functional mechanism of cell membrane proteoglycan and its related enzymes. In addition, he is also trying to discover new target for glycan-based drug discovery and engaging in carbohydrate based new drug development.

1. Non-clinical safety evaluation of drugs, such as traditional Chinese medicines, chemicals and macromolecular biologics, gene and cell therapy products.

2. Mechanisms of hepatotoxicity, nephrotoxicity, pulmonary toxicity

3.Immunotoxicology and immunogenicity of new drug.

1. Discovery and optimization of small-molecule degraders based on proteolysis-targeting chimera (PROTAC) technology.

2. Targeting the key components of the ubiquitin-proteasome system--E3 ubiquitin ligases and deubiquitinating enzymes, design and synthesis of small-molecule modulators of E3 ubiquitin ligases and inhibitors of deubiquitinating enzymes.

3. Targeting the traditional “undruggable targets”, especially protein phosphatase and transcription factors with tumor immunotherapy effects, design and synthesis small-molecule inhibitors\degraders through new strategies for the development of anti-tumor drugs.