Name：Yugen Zhu 朱玉根 Title：Principal Investigator Education：Ph.D Contact Number：0760-85286866 E-mail：zhuyugen@zidd.ac.cn Address：SSIP Healthcare and Medicine Demonstration Zone, Zhongshan Tsuihang New District, Guangdong 528400
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Biography
Dr. Zhu was graduated with his PhD degree from Shanghai Institute of Organic Chemistry (SIOC) (2009-2014) under the supervision of Prof. Biao Yu and received his postdoctoral from the University of Colorado at Boulder (2015-2016) with Prof. Xiang Wang and University of Georgia with Prof. Geert-Jan Boons. During 2019-2022, Dr Zhu start his independent research work at Yunnan University in China, afte which he moved to ZIDD as a principal investigator.
Research Directions
1. Chemical synthesis of bioactive and complex glycoside and glycans
2. Development of novel and efficient methodology to access glycans
3. Structure bioactivity relationship studies on the bioactive carbohydrate-based compound
Achievements
1. Development of efficient methogology for the construction of complex α-glycosyl phosphosaccharides (Nature Communications. 2022, 13,421)
2. Total synthesis of bioactive natural product acteoside (Org. Lett. 2021, 23, 9210-9215)
Publications
1. Zhang, X.; Yang, Y.; Ding, J.; Zhao, Y.; Zhang, H.; Zhu, Y.* Stereoselective Gold(I)-Catalyzed Approach to the Synthesis of Complex α-Glycosyl Phosphosaccharides. Nat. Commun. 2022, 13, 421.
2. Zhang, X.;# Yang, Y.;# Wang, F.;# Zhou, Z.; Zhang, H.*; Zhu, Y.* An Approach to the Synthesis of Electron-Rich and Hindered Esters and Its Application to the Synthesis of Acteoside. Org. Lett. 2021, 23, 9210-9215.
3. Zhu, Y.;# He, W.;# Wang, W.; Pitsch, C.; Wang, X.; Wang, X.* Enantioselective Tandem Cyclization of Alkyne-Tethered Indoles Using Cooperative Silver(I)/Chiral Phosphoric Acid Catalysis. Angew. Chem. Int. Ed. 2017, 56, 12206-12209.
4. Zhu, Y.; Yu, B.* Characterization of the Isochromen-4-yl-gold(I) Intermediate in the Gold(I)-Catalyzed Glycosidation of Glycosyl ortho-Alkynylbenzoates and Enhancement of the Catalytic Efficiency Thereof. Angew. Chem. Int. Ed. 2011, 50, 8329-8332.
5. Zhu, Y.;# Cleaver, L.;# Wang, W.; Podoll, J.; Walls, S.; Jolly, A.; Wang, X.* Tetracyclic indolines as a novel class of b-lactam-selective resistance-modifying agent for MRSA. Eur. J. Med. Chem. 2017, 125, 130-142.
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