全国同城凤凰楼信息茶楼_51pcmc品茶2024官网_全国兼职凤凰楼信息

1. 2022-now Principle Investigator (PI). Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica,China.

2. 2014-2022 Senior Research Fellow. IMCB. A-Star. Singapore.

3. 2012-2014 Postdoctoral Fellow. Jackson Laboratory. USA.

4. 2006-2012 Nanjing University of Science & Technology, Nanjing, China. Doctoral degree, Biochemical Engineering (Ph.D.) 

5.2002-2006 Nanjing University of Science & Technology, Nanjing, China. Bachelor of Bioengineering (B.A).

1. Humanized Mice Disease Models.

2. Humanized Drug Targets.

3. RNA and Protein Drugs.

1. Established HCC-Immune Humanized Mice Models. （Gut,2018）

2. Revealed the functions of HMGB1-TLR4-IL33-IL6-JAK2- STAT3 Signaling Pathway on HCC progression. (Hepatology,2021)

3. Demonstrated the important roles of light-P38-MK2-ROS-HIF1a/BMAL1-CXCR4 in circadian rhythm of blood immune cells.(Blood,2017)

1. Zhao Y# (第一作者) ,Wang J,# Liu WN, Fong SY, Shuen TWH, Liu M, Harden S, Tan SY, Cheng JY, Tan WWS, Kok Yen Chan J, Chee CE, Lee GH, Toh HC, Lim SG, Wan Y, Chen Q. Analysis and validation of human targets and treatments using a hepatocellular carcinoma-immune humanized mouse model. Hepatology. 2021 Sep;74(3):1395-1410.(Original article)

2. Zhao Y (第一作者), Shuen TWH, Toh TB, Chan XY, Liu M, Tan SY, Fan Y,Yang H, Lyer SG, Bonney GK, Loh E, Chang KTE, Tan TC, Zhai W, Chan JKY, Chow EK, Chee CE, Lee GH, Dan YY, Chow PK, Toh HC, Lim SG, Chen Q. Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy. Gut. 2018 Oct;67(10):1845-1854. (Original article). Highlight by editor (Poirier N, Vanhove B. Dynamic human immune and tumour cells cross-talk in PDX-humanised mice warrants checkpoint inhibitor cancer immunotherapies assessment. Gut. 2018 Oct;67(10):1753-1754.)

3. Zhao Y(第一作者), Liu M, Chan XY, Tan SY, Subramaniam S, Fan Y, Loh E, Chang KTE, Tan TC, Chen Q. Uncovering the mystery of opposite circadian rhythms between mouse and human leukocytes in humanized mice. Blood. 2017 Nov 2;130(18):1995-2005. (Regular article). Highlight as editor choice (Simón Méndez-Ferrer. Human and mouse leukocytes: different clockwork Blood 2017 130:1960-1961) 

4. Zhao Y(第一作者), Zhang Y, Zhou M, Wang S, Hua Z, Zhang J. Loss of mPer2 increases plasma insulin levels by enhanced glucose-stimulated insulin secretion and impaired insulin clearance in mice. FEBS Lett. 2012. 586(9):1306-11.

5. Zhao Y(第一作者), Zhang Y, Wang S, Hua Z, Zhang J. The clock gene Per2 is required for normal platelet formation and function. Thromb Res.2011. 127(2):122-30.

6.Zhao Y#, Cheng R#, Zhao Y # ,Ge W, Yang Y, Ding Z, Xu X, Wang Z, Wu Z, Zhang J. Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid. J Biol Chem. 2021 Oct;297(4):101166.

7. Sun Q#, Zhao Y#, Yang Y, Yang X, Li M, Xu X, Wen D, Wang J, Zhang J. Loss of the clock protein PER2 shortens the erythrocyte life span in mice. J Biol Chem. 2017 Jul 28;292(30):12679-12690.