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Guangsen received his bachelor’s degree from the School of Life Science, Nanjing University in 2008. He received PhD from Model Animal Research Center (MARC), Nanjing University in 2014. During his PhD career, he studied the molecular mechanism of the circadian clock feedback loops. Since 2015, he worked as a postdoc scholar in the Ptacek & Fu lab at University of California, San Francisco (UCSF). He screened and had identified several genetic mutations that are responsible for the natural short sleep phenomena. He joined Zhongshan Institute for Drug Discovery (ZIDD) since June, 2021. 

Circadian clock and Sleep

1. Identified three novel short sleep genes: ADRB1, NPSR1 and GRM1 (Neuron 2019, Sci Transl Med 2019, Curr Bio 2021).

2. Discovered the genetic interaction between two clock genes Fbxl3 and Rev-erba (PNAS 2013) and proposed a mathematical model for circadian period determination (Nucleic Acid Research 2014).

3. Identified the novel functions of Histone deacetylase 3 on clock machinery (Cell Reports 2016).

1.Shi Guangsen, Yin Chen, Fan Zenghua, Xing Lijuan, Mostovoy Yulia, Kwok Pui-Yan, Ashbrook Liza H, Krystal Andrew D, Ptá?ek Louis J and Fu Ying-Hui. (2020). Mutations in metabotropic glutamate receptor 1 contribute to natural short sleep trait. Curr Bio. 2021 Jan 11;31(1):13-24.e4. doi.org/10.1016/j.cub.2020.09.071

2. Xing Lijuan#, Shi Guangsen#, Mostovoy Yulia, Gentry Nicholas W, Fan Zenghua, McMahon Thomas B, Kwok Pui-Yan, Jones Christopher R, Ptá?ek Louis J and Fu Ying-Hui.(2019). Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation. Sci Transl Med. 2019 Oct 16;11(514). doi: 10.1126/scitranslmed.aax2014 

3. Shi Guangsen, Xing Lijuan, Wu David, Bhattacharyya Bula J, Jones Christopher R, McMahon Thomas, Chong SY Christin, Chen Jason A, Coppola Giovanni, Geschwind Daniel, Krystal Andrew, Ptá?ek Louis J and Fu Ying-Hui. (2019). A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors. Neuron. 2019 Sep 25;103(6):1044-1055.e7. doi.org/10.1016/j.neuron.2019.07.026

4. Shi Guangsen, Wu David, Ptá?ek Louis J and Fu Ying-Hui.(2017). Human genetics and sleep behavior. Curr Opin Neurobiol. 2017 Mar 15;44:43-49. doi: 10.1016/j.conb.2017.02.015

5. Shi Guangsen#, Xie Pancheng#, Qu Zhipeng, Zhang Zhihui, Dong Zhen, An Yang, Xing Lijuan, Liu Zhiwei, Dong Yingying, Xu Guoqiang, Yang Ling, Liu Yi and Xu Ying.(2016). Distinct roles of HDAC3 in the core circadian negative feedback loop are critical for clock function. Cell Reports. 2016 Feb 2;14(4):823-34. doi.org/10.1016/j.celrep.2015.12.076

6. Yan Jie#, Shi Guangsen#, Zhang Zhihui#, Wu Xi, Liu Zhiwei, Xing Lijuan, Qu Zhipeng, Dong Zhen, Yang Ling and Xu Ying. (2014). An intensity ratio of interlocking loops determines circadian period length. Nucleic acids research.42(16):10278-87. doi: 10.1093/nar/gku701

7. Shi Guangsen#, Xing Lijuan#, Liu Zhiwei, Qu Zhipeng, Wu Xi, Dong Zhen, Wang Xiaohan, Gao Xiang, Huang Moli, Yan Jie, Yang Ling, Liu Yi, Ptacek Louis and Xu Ying (2013). Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock. PNAS. 110, 4750-4755. doi/10.1073/pnas.1302560110