全国同城凤凰楼信息茶楼_51pcmc品茶2024官网_全国兼职凤凰楼信息

Education Experience：

2008.09-2012.06   Shandong University    Bachelor                                                 

2012.09-2017.12 Shanghai Institute of Organic Chemistry,CAS    Ph.D.

Work Experience：

2018.04-2022.04 The Scripps Research Institute Postdoctor                                 

2022.04-2022.07  UF Scripps Biomedical Research Postdoctor

Natural products discovery and biosynthesis, Enzymology, biocatalyst development

Natural products with complex structures are one of the most important sources for new drug discovery. By deciphering the biosynthetic pathways of natural products, the mysterious construction from small building block to complex structures by Nature can be elucidated, thus provides opportunities for new enzymes and enzymatic reactions discovery. Many natural products derivatives can be generated through combinatorial biosynthesis and microbial strains engineering and will enrich the natural products library and facilitate drug discovery.

1. The biosynthesis of Bicyclomycin has been characterized by heterologous biotransformations, in vitro biochemical assays, and one-pot enzymatic synthesis which including regio- and stereoselectively installation of four hydroxy groups and one exo-methylene, as well as forming a medium-sized bridged ring through unactivated C-H bonds functionalization.

2. The sulfur incorporation process for Leinamycin family of natural products has also been investigated, by characterization of an SAM-dependent hydropersulfide methyltransferase for Guangnanmycin biosynthesis, discovery of hydropersulfides as the nascent products of hybrid NRPS-PKS assembly lines and revelation of SH domains as thiocysteine lyases.

1. Meng, S#., Steele, A. D#., Yan, W#., Pan, G.-H., Kalkreuter, E., Liu, Y.-C., Xu, Z.-R. Shen, B*. Thiocytosine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase. Nat. Commun.12,5672-5682 (2021).

2. Yin, Y., Shen, Y., Meng, S., Pan, H.-X. Tang, G.-L*. Characterization of a membrane‐bound O‐acetyltransferase I\involved in Trioxacarcin biosynthesis offers insights into its catalytic mechanism. Chin. J. Chem. 38, 1607-1611 (2020).

3. He, J.-B., Meng, S., Pan, H.-X. Tang, G.-L*. Applications of the multienzyme-catalyzed tandem strategy in the synthesis of complex natural products. Synth. Biol. J. 1, 226-246 (2020).

4. Steele, A. D., Kalkreuter, E., Pan, G.-H. Meng, S. Shen, B*. "Hybrid peptide-polyketide natural product biosynthesis" in in Liu, H.-W.; Begley, T. P. (eds.) Comprehensive natural products III: chemistry and biology. Elsevier. 2, 284-335 (2019).

5. Meng, S., Han, W., Zhao, J., Jian, X.-H., Pan, H.-X*. Tang, G.-L*. A six‐oxidase cascade for tandem C? H bond activation revealed by reconstitution of Bicyclomycin biosynthesis. Angew. Chem. Int. Ed. 130, 727-731 (2018).

6. Hou, X.-F., Song, Y.-J., Zhang, M., Lan, W.-X., Meng, S., Wang, C.-X., Pan, H.-X., Cao, C.- Y. Tang, G.-L*. Enzymology of anthraquinone‐γ‐pyrone ring formation in complex aromatic polyketide biosynthesis. Angew. Chem. Int. Ed. 130, 13663-13667 (2018).

7. Meng, S., Tang, G.-L. Pan, H.-X*. Enzymatic formation of oxygen‐containing heterocycles in natural product biosynthesis. Chembiochem. 19, 2002-2022 (2018).

8. Wu, L.-F., Meng, S. Tang, G.-L. Ferrous iron and α-ketoglutarate-dependent dioxygenases in the biosynthesis of microbial natural products. Biochim. Biophy. Acta. 1864, 453-470 (2016).