Name：Wei Li 李威 Title：Principal Investigator Education：Ph.D Contact Number：0760-85286866 E-mail：liwei1@simm.ac.cn Address：SSIP Healthcare and Medicine Demonstration Zone, Zhongshan Tsuihang New District, Guangdong 528400
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Biography
Wei Li was born in Meizhou, Guangdong Province, China, in 1993. He received his B.S. degree from Guangzhou University of Chinese Medicine in 2015. In the same year, he joined the research group of Professor Sheng Yin as a postgraduate student at School of Pharmaceutical Sciences, Sun Yat-sen University, and obtained his Ph.D. degree in Pharmacognosy in 2020. He continued his postdoctoral research on isolation, structure elucidation, and biological activity studies of natural products in Yin’s group. He joined Shanghai Institute of Materia Medica, Chinese Academy of Sciences (Zhongshan Institute) since August, 2022.
Research Directions
Natural medicinal chemistry
Achievements
A highly efficient tracking and separation system combining LC-MS and characteristic NMR fingerprint was constructed. A series of small molecules with new skeletons were obtained, and a library of Euphorbiaceae diterpenoids was established.
Publications
1. Wei Li, Gui-Hua Tang and Sheng Yin*. Selaginellins from the genus Selaginella: isolation, structure, biological activity, and synthesis. Natural Product Reports, 2021, 38, 822–842.
2. Wei Li, Rui-Min Wang, Yue-Hua Pan, Ying-Yuan Zhao, Fang-Yu Yuan, Dong Huang, Gui-Hua Tang, Hui-Chang Bi, and Sheng Yin*. Crotonpenoids A and B, two highly modified clerodane diterpenoids with a tricyclo[7.2.1.02,7]dodecane core from Croton yanhuii: isolation, structural elucidation, and biomimetic semisynthesis. Organic Letters, 2020, 22, 4435?4439.
3. Wei Li,# Ya-Qi Tang,# Jun Sang, Run-Zhu Fan, Gui-Hua Tang, and Sheng Yin*. Jatrofolianes A and B: two highly modified lathyrane diterpenoids from Jatropha gossypiifolia. Organic Letters, 2020, 22, 106?109.
4. Wei Li, Ya-Qi Tang, Shi-Xin Chen, Gui-Hua Tang, Li-She Gan, Chan Li, Yong Rao, Zhi-Shu Huang, and Sheng Yin*. Euphorhelipanes A and B, triglyceride-lowering Euphorbia diterpenoids with a bicyclo[4.3.0]nonane core from Euphorbia helioscopia. Journal of Natural Products, 2019, 82, 412?416.
5. Wei Li, Li Rao, Yu Liu, Qian He, Yue Fan, Yun-Xia You, Yu Su, Feng Hu, You-Kai Xu, Bin Lin, Sheng Yin, Chuan-Rui Zhang*. (±)-Meliviticines A and B: Rearranged prenylated acetophenone derivatives from Melicope viticina and their antimicrobial activity. Bioorganic Chemistry, 2019, 90, 103099.
6. Wei Li, Yi-Hong Zou, Man-Xi Ge, Lan-Lan Lou, Yun-Shao Xu, Abrar Ahmed, Yun-Yun Chen, Jun-Sheng Zhang, Gui-Hua Tang and Sheng Yin*. Biscembranoids and cembranoids from the soft coral Sarcophyton elegans. Marine Drugs, 2017, 15, 85.
7. Wei Li, Jun-Sheng Zhang, Jia-Luo Huang, Min-Hong Jiang, You-Kai Xu, Abrar Ahmed, Sheng Yin and Gui-Hua Tang*. New prenylated coumarins from the stems of Toddalia asiatica. RSC Advances, 2017, 7, 31061-31068.
8. Wei Li,# Lan-Lan Lou,# Jian-Yong Zhu, Jun-Sheng Zhang, An-An Liang, Jing-Mei Bao, Gui-Hua Tang*, Sheng Yin. New lanostane-type triterpenoids from the fruiting body of Ganoderma hainanense. Fitoterapia, 2016, 115, 24–30.
9. Wei Li,# Gui-Hua Tang,# Lin Chen, Ya-Qi Tang, You-Kai Xu, Bo Liu* and Sheng Yin*. New pyridocarbazole alkaloids from Strychnos nitida. Natural Product Research, 2018, 32, 1532–1536.
10. Yao-Hao Xu,# Wei Li,# Yong Rao, Zhi-Shu Huang, and Sheng Yin*. Pyridocarbazole alkaloids from Ochrosia borbonica: lipid-lowering agents inhibit the cell proliferation and adipogenesis of 3T3-L1 adipocyte via intercalating into supercoiled DNA. Chinese Journal of Natural Medicines, 2019, 17, 663-671.
11. Rong Hu,# Jia-Luo Huang,# Fang-Yu Yuan, Xun Wei, Ming-Feng Zou, Gui-Hua Tang, Wei Li*, and Sheng Yin*. Crotonianoids A-C, three unusual tigliane diterpenoids from Croton tiglium and their anti-prostate cancer activity. Journal of Organic Chemistry, 2022, 87, 9301–9306.
12. Ming-Feng Zou,# Yue-Hua Pan,# Rong Hu, Fang-Yu Yuan, Dong Huang, Gui-Hua Tang, Wei Li*, and Sheng Yin*, Highly modified nor-clerodane diterpenoids from Croton yanhuii. Fitoterapia, 2021, 153 104979.
13. Zhao Yin, Xing-Lin Xie, Jiao Yuan, Yao Zhang, and Wei Li*. Two new ent-abietane diterpenoids from Euphorbia helioscopia. Journal of Asian Natural Products Research, 2020, 22, 632–638.
14. Xing-Lin Xie, Guo-Hua Ye, Jun-Juan Xue, Tong Su, Gui-Hua Tang, Wei Li*, and Sheng Yin*. A new prenylated coumarin and a new anthranilamide derivative from Evodia lepta. Journal of Asian Natural Products Research, 2020, 22, 413–417.
15. Jun Sang, Wei Li, Hong-Juan Diao, Run-Zhu Fan, Jia-Luo Huang, Lu Gan, Ming-Feng Zou, Gui-Hua Tang, and Sheng Yin*, Jolkinolide B targets thioredoxin and glutathione systems to induce ROS-mediated paraptosis and apoptosis in bladder cancer cells. Cancer Letters, 2021, 509, 13-25.
16. Lan-Lan Lou, Wei Li, Bin-Hua Zhou, Lin Chen, Han-Zhuang Weng, Yi-Hong Zou, Gui-Hua Tang, Xian-Zhang Bu, Sheng Yin*. (+)-Isobicyclogermacrenal and spathulenol from Aristolochia yunnanensis alleviate cardiac fibrosis by inhibiting transforming growth factor β/small mother against decapentaplegic signaling pathway. Phytotherapy Research, 2019, 33, 214–223.
17. Fu-Qiang Ni, Shu-Qi Wu, Wei Li, Qingjiang Li,* and Sheng Yin*. Stereoselective construction of the methylcyclopentane core of peditithins B?H with five continuous stereocenters. Organic Letters, 2020, 22, 9360?9364.
18. Run-Zhu Fan,# Lin Chen,# Tong Su, Wei Li, Jia-Luo Huang, Jun Sang, Gui-Hua Tang, and Sheng Yin*. Discovery of 8,9-seco-ent-kaurane diterpenoids as potential leads for the treatment of triple-negative breast cancer. Journal of Medicinal Chemistry, 2021, 64, 9926?9942.
19. Jianyong Zhu,# Ruimin Wang,# Lanlan Lou, Wei Li, Guihua Tang, Xianzhang Bu*, and Sheng Yin*. Jatrophane diterpenoids as modulators of P?glycoprotein-dependent multidrug resistance (MDR): advances of structure?activity relationships and discovery of promising MDR reversal agents. Journal of Medicinal Chemistry, 2016, 59, 6353–6369.
20. Dong Huang,# Rui-Min Wang,# Wei Li, Ying-Yuan Zhao, Fang-Yu Yuan, Xue-Long Yan, Ye Chen, Gui-Hua Tang, Hui-Chang Bi,* and Sheng Yin*. Lathyrane diterpenoids as novel hPXR agonists: isolation, structural modification, and structure?activity relationships. ACS Medicinal Chemistry Letters, 2021, 12, 1159?1165.
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