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Ping Li graduated from Shanghai Institute of Materia Medica, Chinese Academy of Sciences and got Doctor degree in 2014. After graduation, I successively entered the Shenzhen Advanced Technology Research Institute of the Chinese Academy of Sciences and the University of Michigan in the United States for postdoctoral research. I have an interdisciplinary background in biology, chemistry and equipment, and is good at using patch clamp electrophysiological methods to study the physiological and pathological functions of ion channels. After joining the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences and the Zhongshan Institute for Drug Discovery of the Chinese Academy of Sciences in January 2021, our group mainly focuses on the research and development of new drugs for human neuropsychiatric diseases and metabolic diseases, such as Parkinson's disease, epilepsy, pain, diabetes and obesity. The laboratory is characterized by focusing on exploring the relationship between various organelles in cells (mainly lysosomes, autophages, endoplasmic reticulum, mitochondria, etc.) and diseases, and developing new ion channel drugs targeting new ion channels expressed on the surface of organelles. At present, I have published 15 academic papers, and participated in the development of a series of potential small molecule drugs against Parkinson's disease and epilepsy.

Neurodegenerative diseases and lysosome ion channels

Neuropharmacology and ion channel pharmacology

1. Identifying and clarifying the first hydrogen ion channel of lysosome, which is a potential target for the development of anti-Parkinson's disease drugs.

2.  Clarifying the new molecular mechanism and function of lysosome in regulating cell volume.

3. Confirming that the voltage sensitive region of Kv7.2 potassium channel is a new target for the development of antiepileptic drugs。

Participating in screening of various of ion channel drugs, and obtain a series of lead compounds and candidate drugs with diverse structures.

1. Meiqin Hu^#,*, Ping Li^#, Ce Wang^#, Xinghua Feng, Qi Geng, Wei Chen, Matangi Marthi, Wenlong Zhang, Chenlang Gao, Whitney Reid, Joel Swanson, Wanlu Du, Richard I. Hume, Haoxing Xu*, Parkinson`s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes; Cell 2022 June 23; 185(13):2292-2308.

2. Ping Li*, Meiqin Hu, Ce Wang, Xinghua Feng, Zhuangzhuang Zhao, Ying Yang, Nirakar Sahoo, Mingxue Gu, Yexin Yang, Shiyu Xiao, Rajan Sah, Timothy L. Cover, Janet Chou, Raif Geha, Fernando Benavides, Richard I. Hume* and Haoxing Xu；LRRC8 family proteins within Lysosomes Regulate Cellular Osmoregulation and Enhance Cell Survival to Multiple Physiological Stresses. PNAS 2020 Nov. 17;117(46):29155-29165.

3. Ping Li^#, Mingxue Gu^# and Haoxing Xu*；Lysosomal ion channels as decoders of cellular signals. Trends in Biochemical Sciences 2019 Feb; 44(2):110-124.

4. Xiaoli Zhang^#,*, Wei Chen^#, Ping Li^#, Raul Calvo, Noel Southall, Xin Hu, Melanie Bryant-Genevier, Xinghua Feng, Qi Geng, Chenlang Gao, Meimei Yang, Kaiyuan Tang, Marc Ferrer, Jan Jose Marugan, Haoxing Xu*；Agonist-specific voltage-dependent gating of lysosomal two-pore Na⁺ channels. eLIFE 2019; 8:e51423.

5. Ping Li^#, Zhuxi Chen^#, Haiyan Xu, Haifeng Sun, Hao Li, Hong Liu, Huaiyu Yang*, Zhaobing Gao*, Hualiang Jiang*, and Min Li, The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands. Cell Research 2013 Sep; 23(9); 1106-18.