全国同城凤凰楼信息茶楼_51pcmc品茶2024官网_全国兼职凤凰楼信息

EDUCATION
09/2002 - 07/2005 Zhejiang University, Ph.D.
09/1999 - 07/2002 Guangzhou University of Chinese TCM, M.S.
09/1995 - 07/1999 Guangzhou University of TCM, B.S.

WORK EXPERIENCE
07/2020 – present Zhongshan Institute for Drug Discovery, SIMM, CAS; Principal Investigator & Director of Pharmaceutical Research Center

07/2010 - present Shanghai Institute of Materia Medica, CAS
09/2008 - 06/2010 University of Michigan, Senior Research Fellow
11/2005 - 08/2008 University of Michigan, Research Fellow

1. Transdermal drug delivery

2. Macromolecular drug delivery

3. Nanomedicine

4. Insoluble drug delivery technologies

1．We applied the cell-penetrating peptide-based nanotechology to overcome the tissue/cell biobarriers for enhanced anticancer drug delivery.

2．We applied cell-penetrating peptides and nanotechnology for mediating antigen percutaneous absorption. Such methods could be used for non-invasive transcutaneous immunization.

1.Zhen ZN, Zhang JX, Jiang JZ, He Y, Zhang WY, Mo XP, Kang XJ, Xu Q*, Wang B, Huang YZ*. Remodeling Tumor Immune Microenvironment (TIME) for Glioma Therapy Using Multi-Targeting Liposomal Codelivery. Journal for ImmunoTherapy of Cancer 2020, in press. DOI: 10.1136/jitc-2019-000207

2.Zhao YG, Yang YT, Zhang JX, Wang R, Cheng BY, Kalambhe D, Wang YS, Gu ZY, Chen DY*, Wang B*, Huang YZ*. Lactoferrin-mediated macrophage targeting delivery and patchouli alcohol-based therapeutic strategy for inflammatory bowel diseases. Acta Pharmaceutica Sinica B 2020, in press

3.Chen BF, Gao A, Tu B, Wang YH, Yu XL, Wang YS, Xiu YF, Wang B, Wan YK, Huang YZ* Metabolic modulation via mTOR pathway and anti-angiogenesis remodels tumor microenvironment using PD-L1-targeting codelivery. Biomaterials, 2020. 255:120187

4.Yin WM, Zhao YG, Kang XJ, Zhao PF, Fu X, Mo XP, Wang YH, Wan YK, Huang YZ*. BBB-penetrating codelivery liposomes treat brain metastasis of non-small cell lung cancer with EGFRT790M mutation. Theranostics 10(14): 6122

5.Wang HR, Huang YZ*. Combination Therapy Based on Nano Codelivery for Overcoming Cancer Drug Resistance. Medicine in Drug Discovery, 2020: 100024

6.Chang Y, Jiang J, Chen W, Yang W, Chen L, Chen P, Shen J, Qian S, Zhou T, Wu LF, Hong L, Huang YZ*, Li F*. Biomimetic metal-organic nanoparticles prepared with a 3D-printed microfluidic device as a novel formulation for disulfiram-based therapy against breast cancer. Applied Materials Today 2020, 18: 100492

7.Zhang JX, Zhao YG, Hou T, Zeng H, Kalambhe C, Wang B*, Shen X, Huang YZ*. Macrophage-based nanotherapeutic strategies in ulcerative colitis. Journal of Controlled Release 2020, 320:363 (Back cover)

8.Tu B, Zhang M*, Liu T, Huang YZ*. Nanotechnology-Based Histone Deacetylase Inhibitors for Cancer Therapy. Frontiers in Cell and Developmental Biology 2020, 8: 400

9.Asrorov AM, Gu Z, Min KA, Shin MC*, Huang YZ* Advances on Tumor-Targeting Delivery of Cytotoxic Proteins. ACS Pharmacology & Translational Science 2020, 3(1): 107

10.Ouyang X, Wang X, Kraatz HB, Ahmadi S, Gao J, Lv Y, Sun X*, Huang YZ*. A Trojan horse biomimetic delivery strategy using mesenchymal stem cells for PDT/PTT therapy against lung melanoma metastasis. Biomaterials Science 2020, 8: 1160

11.Zhong HH, Wang HY*, Li J, Huang YZ*. TRAIL-based gene delivery and therapeutic strategies Acta Pharmacologica Sinica, 2019, 40: 1373

12.Sun XY*, Zeng LH, Huang YZ*. Transcutaneous Delivery of DNA/mRNA for Cancer Therapeutic Vaccination. Journal of Gene Medicine 2019, 21(7): e3089

13.Wang HR, Tang YS, Fang YF, Zhang M, Wang HY, He ZD, Wang B, Xu Q, and Huang YZ*. Reprogramming Tumor Immune Microenvironment (TIME) and 2 Metabolism via Biomimetic Targeting Codelivery of Shikonin/JQ1. Nano Letters 2019, 19(5):2935

14.Zhang WY, Kang XJ, Yuan B, Wang HY, Zhang T, Shi MJ, Zheng ZN, Zhang YH, Peng CY, Fan XM, Shen YQ, Huang YZ*. Nano-structural effects on gene transfection: large, botryoid-shaped nanoparticles enhance DNA delivery via macropinocytosis and effective dissociation, Theranostics 2019, 9(6):1580-98

15.Chang Y, Yao S, Chen YF, Huang JJ, Wu AH, Zhang M, Xu Fan, Li F ang Huang YZ*. Genetically-engineered protein prodrug-like nanoconjugates for tumor-targeting biomimetic delivery via a SHEATH strategy. Nanoscale 2019, 11: 611-621.

16.Jin HY, He Y, Zhao PF, Hu Y*, Tao J, Chen J, Huang YZ*. Targeting lipid metabolism to overcome EMTassociated drug resistance via integrin β3/FAK pathway and tumor-associated macrophage repolarization using legumain-activatable delivery. Theranostics 2019, 9(1): 265-278 (Front cover).

17.Chen W, Yang W, Chen PY, Huang YZ*, Feng L*. Disulfiram Copper Nanoparticles Prepared with a Stabilized Metal Ion Ligand Complex Method for Treating Drug-Resistant Prostate Cancers. ACS Appl. Mater. Interfaces 2018, 10(48): 41118-41128

18.Zhao PF, Wang HY, Wu AH, Rao YF, and Huang YZ*. Roles of Albumin-Binding Proteins in Cancer Progression and Biomimetic Targeted Drug Delivery. Chembiochem 2018, 19(17): 1796-1805.

19.Yin WM, Yu XL, Kang XJ, Zhao YG, Zhao PF, Jin HY, Fu XH, Wan YK*, Peng CY, and Huang YZ*. Remodeling Tumor-Associated Macrophages and Neovascularization Overcomes EGFRT790M-Associated Drug Resistance by PD-L1 Nanobody-Mediated Codelivery. Small 2018, 14(47): 1802372.

20.Mo XP, Zheng ZN, He Y, Zhong HH, Kang XJ, Shi MJ, Liu TB, Jiao Z, Huang YZ*. Antiglioma via regulating oxidative stress and remodeling tumor-associated macrophage using lactoferrin-mediated biomimetic codelivery of simvastatin/fenretinide. Journal of Controlled Release 2018, 287: 12-23.

21.Kang XJ, Zheng ZN, Liu ZH, Wang HY, Zhao YG, Zhang WY, Shi MJ, He Y, Cao Y, Xu Q*, Peng CY, Huang YZ*. Liposomal Codelivery of Doxorubicin and Andrographolide Inhibits Breast Cancer Growth and Metastasis. Molecular Pharmaceutics 2018, 15, 1618-1626.

22.Zhao PF, Wang YH, Kang XJ, Wu AH, Yin WM, Tang YS, Wang JY, Zhang M, Duan Y and Huang YZ*. Dual-Targeting Biomimetic Delivery for Antiglioma via Remodeling Tumor Microenvironment and Directing Macrophage-Mediated Immunotherapy. Chemical Science 2018, 2674–2689 (Back front cover)

23.Xu F, Zhong HH, Chang Y, Li DD, Jin HY, Zhang M, Wang HY, Jiang C, Shen YQ, Huang YZ*. Targeting death receptors for drug-resistant cancer therapy: Codelivery of pTRAIL and monensin using dual-targeting and stimuliresponsive self-assembling nanocomposites. Biomaterials 2018, 158:56-73

24.Li DD, Zhang M, Xu F, Chen YZ, Chen BF, Chang Y, Zhong HH, Jin HY, Huang YZ*. Biomimetic albumin-modified gold nanorods for photothermo-chemotherapy and macrophage polarization modulation. Acta Pharmaceutica Sinica B 2018, 8(1): 74-84 (Back front cover)

25.Chen YZ, Zhang M, Min KA, Wang HY, Shin MC*, Li F, Yang V, Huang YZ*. Improved Protein Toxin Delivery Based on ATTEMPTS Systems. Current Drug Targets 2018, 19(4): 380-392

26.He Y, Li F*, Huang YZ*. Smart Cell-Penetrating Peptide-Based Techniques for Intracellular Delivery of Therapeutic Macromolecules. Adv Protein Chem Struct Biol. 2018;112:183-220

27.Peng HG, Chen BF, Huang W, Tang YB, Jiang YF, Zhang WY, Huang YZ*. Reprogramming Tumor-Associated Macrophages to Reverse EGFR(T790M) Resistance by Dual-Targeting Codelivery of Gefitinib/Vorinostat. Nano Letters 2017, 17(12): 7684-90

28.Zhao PF, Yin WM, Wu AH, Tang YS, Wang JY, Pan ZZ, Lin TT, Zhang M, Chen BF, Duan Y, Huang YZ*. Dual-Targeting to Cancer Cells and M2 Macrophages via Biomimetic Delivery of Mannosylated Albumin Nanoparticles for Drug-Resistant Cancer Therapy. Advanced Functional Materials 2017, 27(44): 1700403 (Front Cover)

29.Chen YZ, Zhang M, Jin HY, Li DD, Xu F, Wu AH, Wang JY, Huang YZ*. Glioma Dual-Targeting Nanohybrid Protein Toxin Constructed by Intein-Mediated Site-Specific Ligation for Multistage Booster Delivery. Theranostics 2017, 7(14): 3489-503

30.Xu JJ, Xu BH, Tao J, Yang YX, Hu Y*, Huang YZ*. Microneedle-Assisted, DC-Targeted Codelivery of pTRP-2 and Adjuvant of Paclitaxel. Small 2017, 13(28): 1700666

31.Chen YZ, Zhang M, Jin HY, Tang YS, Wang HY, Xu Q, Li YP, Li F, Huang YZ*. Intein-mediated site-specific synthesis of tumor-targeting protein delivery system: Turning PEG dilemma into prodrug-like feature. Biomaterials 2017, 116: 57-68

32.Tang YS, Liang JM, Wu AH, Chen YZ, Zhao PF, Lin TT, Zhang M, Xu Q*, Wang JM*, Huang YZ*. Co-Delivery of Trichosanthin and Albendazole by Nano-Self-Assembly for Overcoming Tumor Multidrug-Resistance and Metastasis. ACS Applied Materials & Interfaces 2017, 9(32): 26648-64

33.Pan ZZ, Kang XJ, Zeng YE, Zhang WY, Peng HG, Wang JY, Huang W, Wang HY*, Shen YQ, Huang YZ*. A mannosylated PEI–CPP hybrid for TRAIL gene targeting delivery for colorectal cancer therapy. Polymer Chemistry 2017, 8(35): 5275-85 (Front Cover)

34.Chen YZ, Zhang M, Jin HY, Tang YS, Wu AH, Xu Q, Huang YZ*. Prodrug-Like, PEGylated Protein Toxin Trichosanthin for Reversal of Chemoresistance. Molecular Pharmaceutics 2017, 14(5): 1429-38

35.Tan J, Wang HY, Xu F, Chen YZ, Zhang M, Peng HG, Sun X*, Shen YQ, Huang YZ*. Poly-γ-glutamic acid-based GGT-targeting and surface camouflage strategy for improving cervical cancer gene therapy. Journal of Materials Chemistry B 2017, 5:1315-1327

36.Kan XJ, Wang HY, Peng HG, Chen BF, Zhang WY, Wu AH, Xu Q*, Huang YZ*. Codelivery of dihydroartemisinin and doxorubicin in mannosylated liposomes for drug-resistant colon cancer therapy. Acta Pharmacologica Sinica 2017, 38(6): 885-96 (Serving as Co-Guest Editors for the featured issue)

37.Zhang M, Liu E, Cui Y, Huang YZ*. Nanotechnology-based combination therapy for overcoming multidrug-resistant cancer. Cancer Biology & Medicine 2017, 14(3): 212-27

38.Wang HY, Moon C, Shin MC, Wang YP, He HN, Yang V*, Huang YZ*. Heparin-Regulated Prodrug-Type Macromolecular Theranostic Systems for Cancer Therapy. Nanotheranostics 2017, 1(1): 114-30

39.Lin TT, Zhao PF, Jiang YF, Tang YS, Jin HY, Pan ZZ, He HN, Yang V, Huang YZ*. Blood–Brain-Barrier-Penetrating Albumin Nanoparticles for Biomimetic Drug Delivery via Albumin-Binding Protein Pathways for Antiglioma Therapy. ACS Nano 2016, 10:9999-10012

40.Cui YN, Zhang M, Zeng F, Jin HY, Xu Q, Huang YZ*. Dual-targeting magnetic PLGA nanoparticles for codelivery of paclitaxel and curcumin for brain tumor therapy. ACS Applied Materials & Interfaces 2016, 8: 32159-32169

41.Lin TT, Liu EG, He HN, Shin MC, Moon C, Yang V*, Huang YZ*. Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides. Acta Pharmaceutica Sinica B 2016, 6: 352–358 (Back front cover)

42.Pan ZZ, Wang HY, Zhang M, Lin TT, Zhang WY, Zhao PF, Tang YS, Xiong Y, Zeng YE* and Huang YZ*. Nuclear-targeting TAT-PEG-Asp8-doxorubicin polymeric nanoassembly to overcome drug-resistant colon cancer. Acta Pharmacologica Sinica 2016, 37: 1110–1120 (Editor choice)