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Tie-Gen Chen, Ph.D., Principal investigator of Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Zhongshan Institute for Drug Discovery. Dr. Chen received his B.Sc. in chemistry from Sichuan University in 2009. He obtained his PhD at Shanghai Institute of Organic Chemistry (SIOC) under the supervision of Prof. Li-Xin Dai and Prof. Xue-Long Hou in 2014. In 2016, he joined the laboratory of Prof. Phil S. Baran as a postdoctoral fellow at The Scripps Research Institute (TSRI). Since September 2020, Dr. Chen has worked at Shanghai Institute of Materia Medica, Chinese Academy of Sciences. His current research interests are mainly focused on the innovative radical chemistry and medicinal chemistry. 

1.Novel synthetic methodologies (radical chemistry);

2.Total synthesis and structural modification of natural products;

3.Discovery of lead compounds and candidate compounds;

4.Construction of bioactive small molecules library.

1. We developed a new protocol, which enabled the coupling of general tertiary systems using nickel catalysis. The scope of this operationally simple method was broad, and it could be used to simplify the synthesis of medicinally relevant motifs bearing quaternary centers.

2. We conceived and demonstrated a strategy for combining the optimal features of these two chemical transformations, classic cycloaddition chemistry and newly emerging radical C–C coupling, into one simple sequence, to enable the modular, enantioselective, scalable and programmable preparation of useful building blocks, natural products and lead scaffolds for drug discovery.

1. Convergent Synthesis of (R)-Silodosin via Decarboxylative Cross-coupling. Chen, T. -G.; Mele, L.; Jentzer, O.; Delbrayelle, D.; Echeverria, P.-G.; Vantourout, J. C.; Baran, P. S. Tetrahedron Lett. 2021, 79, 153290.

2. Quaternary Centers via Ni-Catalyzed Cross-Coupling of Tertiary Carboxylic Acids and Aryl Zinc Reagents. Chen, T. -G.; Zhang, H.; Mykhailiuk, P. K.; Merchant, R. R.; Smith, C. A.; Qin, T.; Baran, P. S. Angew. Chem. Int. Ed. 2019, 58, 2454.

3. Building C(sp3)-rich complexity by combining cycloaddition and C–C cross-coupling reactions, Chen, T.-G.#; Barton, L. S.#; Lin, Y.#; Tsien, J.; Kossler, D.; Bastida, I.; Asai, S.; Bi, C.; Chen, J. S.; Shan, M.; Fang, H.; Fang, F. G.; Choi, H.; Hawkins, L.; Qin, T.; Baran, P. S. Nature 2018, 560, 350. (#co-first author)

4. Redox-Active Esters in Fe-catalyzed C-C Coupling, Toriyama, F.#; Cornella, J.#; Wimmer, L.; Chen, T.-G.; Dixon, D. D.; Creech, G.; Baran, P. S. J. Am. Chem. Soc. 2016, 138, 11132.5. Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids, Wang, J.; Qin, T.; Chen, T.-G.; Wimmer, L.; Edwards, J. T.; Cornella, J.; Vokits, B.; Shaw, S. A.; Baran, P. S. Angew. Chem. Int. Ed. 2016, 55, 9676.