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Biography

Junyu Xu is an associate professor in the department of chemistry and proteomics at Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences (China).

Junyu Xu graduated with B.Sc. in Biotechnology in 2012 from East China University of Science & Technology. He received his Ph.D. in Biochemistry and Molecular Biology from East China University of Science & Technology in 2017. He joined Minjia Tan’s group and became a post-doctoral fellow in proteomic filed at Shanghai Institute of Materia Medica. And he was awarded associate professor by SIMM in 2020.

With backgrounds in Proteomics, Chemical Biology and Pharmacology, Junyu Xu utilized comprehensive chemical proteomics and clinical proteomics approaches to conduct highly innovative interdisciplinary research on the elucidation of Protein/PTM regulatory mechanism and mediated pathways, and characterization of their roles in precision medicine and drug development. In the comprehensive proteomic analysis based on patients with lung adenocarcinoma (LUAD) (Cell 2020), he and collaborators uncovered LUAD-related molecular characteristics, their association with clinical outcomes, potential prognostic biomarkers and drug targets, providing new insights on LUAD beyond the current genomic understanding. This study serves as a valuable and powerful resource for expediting the translation of basic research into more precise diagnosis and therapeutic treatments in clinical practice. Several research articles of him were published in SCI journal, including Cell, Cell Chemical Biology, Journal of Proteome Research, mSystems, ACS Chemical Biology, Molecular&Cellular Proteomics, and Proteomics.

Research Directions

Study on Disease Treatment Strategies based on proteomics

Achievements

The representative work of Junyu Xu in the past five years. He conducted the proteomic landscape of LUAD, and screened potential biomarkers and therapeutic drug target. This study provided valuable resource for LUAD precision medicine and promoted the current understanding of LUAD pathology from genomic level to proteomic level (Cell, 2020). He uncovered that dysregulation of DRAk2-dependent RNA splicing of mitochondrial-related genes, was a novel pathological mechanism and therapeutic drug target in NAFLD. Meantime, pharmaceutical interventions targeting the kinase Drak2 alleviated the disease process (Cell Metab, 2021). He explored the universality, dynamic and diversity of multiple lysine modifications in various physiological and pathological models and uncovered the specific biological regulatory effects of lysine acylations (J Proteomics, 2022; Cell Chem Biol, Cell 2018). He developed a novel proteomic strategy for exploring the tumor resistance mechanism of epigenetic inhibitors (J Proteome Res, 2022).

Junyu Xu was awarded the Rising Star in Proteomics selected by Journal of Proteome Research journal in 2021, the Outstanding Young Scholar Report Award in the 10th CNHUPO Conference in 2018 (CNHUPO, China), the nominee of 2021 Shanghai Science & Technology 35 Under 35, the SANOFI-SIBS Post-doctoral Fellowship in 2018 (Sanofi and SIBS, China).

Junyu Xu presided 7 projects, including National Natural Science Foundation of China (31901036), the Youth Innovation Promotion Association CAS (2021276), the Young Elite Scientists Sponsorship Program by CAST (2022QNRC001), Shanghai Rising Star Project (22QA1411100), and Shanghai Sailing Project Foundation (19YF1457700).

Publications

1. Xu JY#, Zhang CC#, Wang X#, Zhai LH#, Ma YM#, Mao YS, Qian K, Sun CQ, Liu ZW, Jiang SW, Wang MH, Feng L, Zhao L, Liu P, Wang B, Zhao X, Xie H, Yang XY, Zhao LY, Chang YF, Jia JY, Wang XJ, Zhang YM, Wang YR, Yang YK, Wu ZX, Yang LH, Liu B, Zhao T, Ren SG, Sun AH, Zhao Y, Ying WT, Wang F, Wang GS, Zhang Y, Cheng SJ, Qin J, Qian XH, Wang Y*, Li J*, He FC*, Xiao T*, Tan M*. (2020) Integrative proteomic characterization of human lung adenocarcinoma. Cell. 182: 245-261, e17.

2. Li YF#, Xu, JY#, Lu YT#, Bian H#, Yang L, Wu HH, Zhang XW, Zhang BL, Xiong MQ, Chang YF, Tang J, Yang F, Zhao L, Li J, Gao X, Xia MF, Tan M, Li JY (2021). DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing. Cell Metab. 33:2004-2020.e9.

3. Liu Q#, Hao BB#, Zhang MY, Liu ZW, Huang YQ, Zhao XX, Hu H, Tan M*, Xu, JY* (2021). An Integrative Proteome-Based Pharmacologic Characterization and Therapeutic Strategy Exploration of SAHA in Solid Malignancies. J Proteome Res. 21:953-964.

4. Zhang MY#, Liu Q#, Huang YQ, Wang L, Tan M*, Xu, JY* (2022). Comparative proteomic and phosphoproteomic analysis of Mycobacteria treated with flavonoid quercetin and non-flavonoid caffeic acid. Int J Mass Spectrom. 482:116934.

5. Zhang MY#, Liu TX#, Wang L, Huang YQ, Fan RF, Ma K, Kan YB, Tan M*, Xu, JY* (2023). Global landscape of lysine acylomes in Bacillus subtilis. J Proteomics. 271: 104767.

6. Xu JY#, Zhao L#, Xu Y, Li B, Zhai L, Tan M*, Ye BC*. (2020) Dynamic Characterization of Protein and Posttranslational Modification Levels in Mycobacterial Cholesterol Catabolism.  mSystems.  5: e00424-19.

7. Hao BB#, Sun MW#, Zhang M#, Zhao XX, Zhao L, Li BL, Zhai LH, Liu P, Hu H, Xu JY*, Tan M*. (2020) Global Characterization of Proteome and Lysine Methylome Features in EZH2 Wild-type and Mutant Lymphoma Cell Lines. J Proteomics. 213: 103614.

8. Xu JY^#, Xu Y^#, Xu Z, Zhai LH, Ye Y, Zhao Y, Chu X, Tan M*, Ye BC* (2018) Protein Acylation is a General Regulatory Mechanism in Biosynthetic Pathway of Acyl-CoA-Derived Natural Products. Cell Chem Biol. 25: 984-995.

9. Xu JY, Xu Y, Chu X, Tan M*, Ye BC*. (2018) Protein Acylation Affects the Artificial Biosynthetic Pathway for Pinosylvin Production in Engineered E. coli. ACS Chem Biol. 13: 1200-1208.

10. Xu JY#, Zhao L#, Liu X, Hu H, Liu P, Tan M*, Ye BC*. (2018) Characterization of the Lysine Acylomes and the Substrates Regulated by Protein Acyltransferase in Mycobacterium smegmatis. ACS Chem Biol. 13: 1588-1597.

11. Xu JY#, Xu Z#, Liu X, Tan M, Ye BC (2018) Protein Acetylation and Butyrylation Regulate the Phenotype and Metabolic Shifts of the Endospore-forming Clostridium acetobutylicum. Mol Cell Proteomics. 17: 1156-1169.

12. Zhang M#, Xu JY#, Hu H, Ye BC*, Tan M*. (2018) Systematic Proteomic Analysis of Protein Methylation in Prokaryotes and Eukaryotes Revealed Distinct Substrate Specificity. Proteomics. 18: 1700300. 

13. Xu JY, Xu Z, Zhou Y, Ye BC*. (2016) Lysine Malonylome May Affect the Central Metabolism and Erythromycin Biosynthesis Pathway in Saccharopolyspora erythraea, J Proteome Res. 15: 1685-1701.

14. Xu JY, You D, Leng PQ, Ye BC*. (2014) Allosteric Regulation of a Protein Acetyltransferase in Micromonospora aurantiaca by the Amino Acids Cysteine and Arginine, J Biol Chem. 289: 27034-27045.