全国同城凤凰楼信息茶楼_51pcmc品茶2024官网_全国兼职凤凰楼信息

Biography

Dr. Likun Gong, Professor, Doctoral supervisor.

Dr. Likun Gong, be enrolled to China Medical University in 1991 for M.D. degree. After her graduation in 2000, she joined Shanghai Institute of Materia Medica (SIMM) of Chinese Academy of Sciences, and has since then started her career in non-clinical drug safety evaluation. She received her PhD in pharmacology in SIMM, CAS in 2005 and completed her postdoctoral research from the University of Tokyo in Japan on pharmaceutical and molecular pharmacokinetics (The Japan Society for the Promotion of Science (JSPS) , postdoctoral fellow) in 2008.

Dr. Likun Gong has more than 25 years of experience in non-clinical drug safety evaluation and toxicological research. Currently she directs the development of key technologies and for non-clinical evaluation of new drugs and establishment of advanced toxicity screening methods in the early development stage of innovative drugs in the CDSER, ZIDD, SIMM.

Besides her efforts on research, she has fully undertaken and participated in more than 20 projects supported by the National Natural Science Foundation of China, the National Science & Technology Major Project ‘Key New Drug Creation Program’ of China, Chinese Academy of Sciences and local government funds. Up to now, her team has published more than 70 articles in reputable Journals and apply for more than 10 patents. As rewards for her commitments, she has personally received The Second prize of the National Science and Technology Progress Award, the First Prize of the Science and Technology Award of the Chinese Pharmaceutical Association, and the First Prize of the Shanghai Pudong Science and Technology Progress Award.

Research Directions

1. Non-clinical safety evaluation of drugs, such as traditional Chinese medicines, chemicals and macromolecular biologics, gene and cell therapy products.

2. Mechanisms of hepatotoxicity, nephrotoxicity, pulmonary toxicity

3. Immunotoxicology and immunogenicity of new drug.

Achievements

2013   The second prize of National Science & Technology Progress Award of People's Republic of China.  Molecular toxicology research, application of key technologies in drug safety assessment and international accreditation (No: 2013-J-235-2-02-R02)

2018 The third prize of Science and Technology Award of Shanghai Pudong (2018), A systematic study on the key factors affecting the mutagenesis of specific target organs induced by aristolochic acid and its molecular mechanism (R4/15)

2017 The first prize of Science and Technology Award of Shanghai Pudong (2017), Establish an international key technology platform for PK/PD and safety evaluation of macromolecule pharmaceuticals (R2/15)

2016   The first prize of Science and Technology Award of Chinese Pharmaceutical Association (2016), Characteristics and molecular mechanisms of specific organs toxicity and metabolism induced by derivatives of Tripterygium wilfordii Hook. F (LeiGongTeng), a traditional Chinese medicine（R03）

2014 The first prize of Science & Technology Award of Pudong in Shanghai, China.  Molecular toxicology research, application of key technologies in drug safety assessment and international accreditation (R02)

2009   The first prize of Science and Technology Award of Chinese Pharmaceutical Association (2009). Ren J, Gong LK, Qi XM, et al. Molecular Toxicological Studies on Active Components in Traditional Chinese Medicines

2009 Award for Excellent Papers in the 5th National Congress of Chinese Society of Toxicology.

2006 JSPS Award：FY2006 JSPS Postdoctoral Fellowship for Foreign Researchers（2006-2008）

2004 Excellent Young Scientist Award, Shanghai Institute of Materia Medica

Publications

1. Yu X#, Long Y#, Chen B, Tong Y, Shan M, Jia X, Hu C, Liu M, Zhou J, Tang F, Lu H, Chen R, Xu P, Huang W, Ren J, Wan Y, Sun J, Li J*, Jin G*, Gong L*. PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way. J Immunother Cancer. 2022 Oct;10(10):e004590. doi: 10.1136/jitc-2022-004590.

2. Zhang J#, Yan X#, Jin Q, Chen J, Yang L, Wei W, Qu H, Yao C, Hou J, Gong L, Wu W*, Guo DA*. Novel triterpenoids from Alisma plantago-aquatica with influence on LDL uptake in HepG2 cells by inhibiting PCSK9. Phytomedicine. 2022 Oct;105:154342. doi: 10.1016/j.phymed.2022.154342. Epub 2022 Jul 16.

3. Zhou L, Liu T, Mo M, Shi Y, Wu L, Li Y, Qin Q, Zhu W*, Wu C*, Gong L*, Xu Z*. Exploring the Binding Affinity and Mechanism between ACE2 and the Trimers of Delta and Omicron Spike Proteins by Molecular Dynamics Simulation and Bioassay. J Chem Inf Model. 2022 Sep 26;62(18):4512-4522. doi: 10.1021/acs.jcim.2c00881. Epub 2022 Sep 2.

4. Qin Q*, Gong L*. Current Analytical Strategies for Antibody-Drug Conjugates in Biomatrices. Molecules. 2022 Sep 24;27(19):6299. doi: 10.3390/molecules27196299.

5. Wu S*, Cao Y, Lu H, Qi X, Sun J, Ye Y*, Gong L*. Aberrant peribiliary gland niche exacerbates fibrosis in primary sclerosing cholangitis and a potential therapeutic strategy. Biomed Pharmacother. 2022 Sep;153:113512. doi: 10.1016/j.biopha.2022.113512. Epub 2022 Aug 4.

6. Liu T#, Tong Y#, Gao J, Fang W, Wu J, Peng X, Fan X, Chen X, Sun J, Cao S, Li Z, Gong L*, Qin Q*, Ju D*.Development of a bridging ELISA for detection of antibodies against ZV0203 in cynomolgus monkey serum. J Pharmacol Toxicol Methods. 2022 Aug 24:107210. doi: 10.1016/j.vascn.2022.107210.

7. Dong Y#, Yu C#, Ma N, Xu X, Wu Q, Lu H, Gong L, Chen J*, Ren J*. MicroRNA-379-5p regulates free cholesterol accumulation and relieves diet induced-liver damage in db/db mice via STAT1/HMGCS1 axis. Mol Biomed. 2022 Aug 10;3(1):25. doi: 10.1186/s43556-022-00089-w.

8. Li F, Long Y, Yu X, Tong Y, Gong L*. Different Immunoregulation Roles of Activin A Compared With TGF-β. Front Immunol. 2022 Jun 14;13:921366. doi: 10.3389/fimmu.2022.921366. eCollection 2022.

9. Cao Y, Shi Y, Song L, Xu J, Lu H, Sun J, Hou J*, Chen J*, Wu W* and Gong L*. Multi-omics integration analysis identifies lipid disorder of non-alcoholic fatty liver disease (NAFLD) mouse model improved by Zexie-Baizhu decoction. Front. Pharmacol. 20 June 2022; https://doi.org/10.3389/fphar.2022.858795. (IF: 5.988)

10. Liu N#, Long H#, Sun J*, Li H, He Y, Wang Q, Pan K, Tong Y, Wang B*, Wu Q*, Gong L*. New laboratory evidence for the association between endothelial dysfunction and COVID-19 disease progression.  J Med Virol. 2022 Jul;94(7):3112-3120. doi: 10.1002/jmv.27693. Epub 2022 Mar 17. (IF:20.693)

11. Jiang Z, Cheng L, Wu Z, Zhou L, Wang H, Hong Q, Wu Q, Long Y, Huang Y, Xu G, Yao Y, Tang Z, Zhang Z, Yang L, Luo W, Yang J, Gong L, Liu P, Chen X, Cui S, Zhang Q, Li Y, Li P. Transforming primary human hepatocytes into hepatocellular carcinoma with genetically defined factors.  EMBO Rep. 2022 Jun 7;23(6):e54275. doi: 10.15252/embr.202154275. Epub 2022 Apr 19. (IF:9.071)

12. Long Y, Yu X, Chen R, Tong Y, Gong L*. Noncanonical PD-1/PD-L1 Axis in Relation to the Efficacy of Anti-PD Therapy.  Front Immunol. 2022 May 18;13:910704. doi: 10.3389/fimmu.2022.910704. eCollection 2022. (IF:8.786)

13. Liu N, Guo YN, Wang XJ, Ma J, He YT, Zhang F, He H, Xie JL, Zhuang X, Liu M, Sun JH, Chen Y, Lin JH, Gong LK*, Wang BS*. Copy Number Analyses Identified a Novel Gene: APOBEC3A Related to Lipid Metabolism in the Pathogenesis of Preeclampsia.  Front Cardiovasc Med. 2022 May 16;9:841249. doi: 10.3389/fcvm.2022.841249. eCollection 2022. (IF:5.846)

14. Liu Y, Zhou P, Cao Z, Liang W, Yan J, Xu H, Wu L, Sun L, Gong L, Peng C, Guo T, Wang C, Zhang J. Simultaneous solubilization and extended release of insoluble drug as payload in highly soluble particles of γ-cyclodextrin metal-organic frameworks.  Int J Pharm. 2022 May 10;619:121685. doi: 10.1016/j.ijpharm.2022.121685. Epub 2022 Mar 19. (IF:6.510)

15. Shi W, Li W, Zhang J, Li T, Song Y, Zeng Y, Dong Q, Lin Z, Gong L, Fan S, Tang F, Huang W*. One-step synthesis of site-specific antibody-drug conjugates by reprograming IgG glycoengineering with LacNAc-based substrates.  Acta Pharm Sin B. 2022 May;12(5):2417-2428. doi: 10.1016/j.apsb.2021.12.013. Epub 2021 Dec 24. (IF:14.903)

16. Cao Y, Liu M, Wu S, Xu J, Wang W, Qi X, Ren J, Sun J, Chen J*, Gong L*. Kupffer cells play a crucial role in monocrotaline-induced liver injury by producing TNF-α. Toxicology. 2022 Feb 28;468:153101. doi: 10.1016/j.tox.2022.153101. Epub 2022 Jan 19. (IF: 4.571)

17. Zhou L, Wu L, Peng C, Yang Y, Shi Y, Gong L, Xu Z*, Zhu W*. Predicting spike protein NTD mutations of SARS-CoV-2 causing immune evasion by molecular dynamics simulations.  Phys Chem Chem Phys. 2022 Feb 2;24(5):3410-3419. doi: 10.1039/d1cp05059a. (IF:3.945)

18. Long Y#, Sun J#, Song TZ#, Liu T#, Tang F#, Zhang X#, Ding L#, Miao Y, Zhu W, Pan X, An Q, Qin M, Tong X, Peng X, Yu P, Zhu P, Xu J, Zhang X, Zhang Y, Liu D, Chen B, Chen H, Zhang L, Xiao G, Zuo J, Tang W, Zhou J, Li H, Xu Z, Zheng HY, Long XY, Qin Q*, Gan Y*, Ren J*, Huang W*, Zheng YT*, Jin G*, Gong L*. CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity. Cell Discov. 2022 Feb 1;8(1):9. doi: 10.1038/s41421-021-00370-2. (IF: 38.079)

19. Wu L#, Zhou L#, Mo M#, Liu T#, Wu C, Gong C, Lu K, Gong L*, Zhu W*, Xu Z*. SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2. Signal Transduct Target Ther. 2022 Jan 5;7(1):8. doi: 10.1038/s41392-021-00863-2. (IF: 38.104)

20. Min Pei, Tingting Liu, Lu Ouyang, Jianhua Sun, Xiaojie Deng, Xiaomin Sun, Wei Wu, Peng Huang, Yi-Li Chen, Xiaorong Tan, Xiaoyue Liu, Peng Zhu, Yongzhen Liu, Deheng Wang, Junliang Wu, Qi Wang, Guifeng Wang, Likun Gong*, Qiuping Qin*, Chunhe Wang*. Enzyme-linked immunosorbent assays for quantification of MMAE-Conjugated ADCs and total antibodies in cynomolgus monkey sera. Journal of Pharmaceutical Analysis. 2021 Nov 24 Online. https://doi.org/10.1016/j.jpha.2021.11.005. (IF:14.026)

21. Song Y, Deng X, Shi W, Tang F, Huang W, Gong L*, Qin Q*. A homogeneous time-resolved fluorometric energy transfer assay for the binding assessment of FcRn with IgG antibodies.J Immunol Methods. 2021 Dec;499:113180. doi: 10.1016/j.jim.2021.113180. (IF:2.287)

22. Dong Y, Ma N, Fan L, Yuan L, Wu Q, Gong L, Tao Z, Chen J*, Ren J*. GADD45β stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation.Pharmacol Res. 2021 Nov;173:105879. doi: 10.1016/j.phrs.2021.105879. (IF:10.334)

23. Liu Y, He X, Wang Y, Zhou H, Zhang Y, Ma J, Wang Z, Yang F, Lu H, Yang Y, Deng Z*, Qi X*, Gong L*, Ren J* .Aristolochic acid I induces impairment in spermatogonial stem cell in rodents.Toxicol Res (Camb). 2021 Apr 26;10(3):436-445. doi: 10.1093/toxres/tfab038. Corrigendum to: Aristolochic acid I induces impairment in spermatogonial stem cell in rodents.  Toxicol Res (Camb). 2021 Jun 18;10(4):959. doi: 10.1093/toxres/tfab061. (IF: 2.680)

24. Xu S, Ge X, Wang L, Tao Y, Tang D, Deng X, Yang F, Zhang Q, Qi X, Gong L*, Yang L*. Profiling pharmacokinetics of double-negative T cells and cytokines via a single intravenous administration in NSG mice.Biopharm Drug Dispos. 2021 Jul;42(7):338-347. doi: 10.1002/bdd.2295. (IF:1.831)

25. Wu S, Lu H, Wang W, Song L, Liu M, Cao Y, Qi X, Sun J*, Gong L*.Prevention of D-GalN/LPS-induced ALI by 18β-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation.Cell Death Dis. 2021 May 13;12(5):480. doi: 10.1038/s41419-021-03768-8. (IF:9.685)

26. Xu X, Dong Y, Ma N, Kong W, Yu C, Gong L, Chen J*, Ren J*.MiR-337-3p lowers serum LDL-C level through targeting PCSK9 in hyperlipidemic mice.Metabolism. 2021 Jun;119:154768. doi: 10.1016/j.metabol.2021.154768. (IF:13.934)

27. Liu YZ, Lu HL, Qi XM, Xing GZ, Wang X, Yu P, Liu L, Yang FF, Ding XL, Zhang ZA, Deng ZP*, Gong LK*, Ren J*.Aristolochic acid I promoted clonal expansion but did not induce hepatocellular carcinoma in adult rats. Acta Pharmacol Sin. 2021 Dec;42(12):2094-2105. doi: 10.1038/s41401-021-00622-7. (IF:7.169)

28. Zhang WT, Liu TT, Wu M, Chen XC, Han L, Shi ZZ, Li YY, Li XY, Xu HX, Gong LK*, Xu PH*, Geng Y*. Development of a nanobody-based immunoassay for the sensitive detection of fibrinogen-like protein 1. Acta Pharmacol Sin. 2021 Nov;42(11):1921-1929. doi: 10.1038/s41401-020-00574-4. (IF:7.169)

29. Liu N, Guo YN, Gong LK*, Wang BS*.Advances in biomarker development and potential application for preeclampsia based on pathogenesis.Eur J Obstet Gynecol Reprod Biol X. 2020 Oct 9;9:100119. doi: 10.1016/j.eurox.2020.100119. (IF:2.831)

30. Fan L, Lai R, Ma N, Dong Y, Li Y, Wu Q, Qiao J, Lu H, Gong L, Tao Z, Chen J*, Xie Q*, Ren J*.miR-552-3p modulates transcriptional activities of FXR and LXR to ameliorate hepatic glycolipid metabolism disorder.J Hepatol. 2021 Jan;74(1):8-19. doi: 10.1016/j.jhep.2020.07.048. (IF:30.083)

31. Wu SY, Wang WJ, Dou JH, Gong LK*.Research progress on the protective effects of licorice-derived 18β-glycyrrhetinic acid against liver injury.Acta Pharmacol Sin. 2021 Jan;42(1):18-26. doi: 10.1038/s41401-020-0383-9. Epub 2020 Mar 6. (IF:7.169)

32. Yan XX, Li HL, Zhang YT, Wu SY, Lu HL, Yu XL, Meng FG, Sun JH*, Gong LK*.A new recombinant MS-superoxide dismutase alleviates 5-fluorouracil-induced intestinal mucositis in mice.Acta Pharmacol Sin. 2020 Mar;41(3):348-357. doi: 10.1038/s41401-019-0295-8. (IF:7.169)

33. Guan D, Chen F, Qiu Y, Jiang B, Gong L, Lan L*, Huang W*.Sulfonium, an Underestimated Moiety for Structural Modification, Alters the Antibacterial Profile of Vancomycin Against Multidrug-Resistant Bacteria.Angew Chem Int Ed Engl. 2019 May 13;58(20):6678-6682. doi: 10.1002/anie.201902210.

34. Zhang YT, Yu YQ, Yan XX, Wang WJ, Tian XT, Wang L, Zhu WL*, Gong LK*, Pan GY*.Different structures of berberine and five other protoberberine alkaloids that affect P-glycoprotein-mediated efflux capacity.Acta Pharmacol Sin. 2019 Jan;40(1):133-142. doi: 10.1038/s41401-018-0183-7.

35. Wu SY, Cui SC, Wang L, Zhang YT, Yan XX, Lu HL, Xing GZ, Ren J, Gong LK*.18β-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway.Acta Pharmacol Sin. 2018 Dec;39(12):1865-1873. doi: 10.1038/s41401-018-0110-y.

36. Zhang Y, Sun J, Tan M, Liu Y, Li Q, Jiang H, Wang H, Li Z, Wan W, Jiang H, Lu H, Wang B, Ren J*, Gong L*.Species-Specific Involvement of Integrin αIIbβ3 in a Monoclonal Antibody CH12 Triggers Off-Target Thrombocytopenia in Cynomolgus Monkeys.Mol Ther. 2018 Jun 6;26(6):1457-1470. doi: 10.1016/j.ymthe.2018.04.005.

37. Zhong W, Li G, Yu X, Zhu M*, Gong L*, Wan Y*.Sensitive detection of Bacillus thuringiensis Cry1B toxin based on camel single-domain antibodies.Microbiologyopen. 2018 Aug;7(4):e00581. doi: 10.1002/mbo3.581.

38. Guan D, Chen F, Xiong L, Tang F, Faridoon, Qiu Y, Zhang N, Gong L, Li J, Lan L, Huang W. Extra Sugar on Vancomycin: New Analogues for Combating Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci. J Med Chem. 2018 Jan 11;61(1):286-304. doi: 10.1021/acs.jmedchem.7b01345.

39. Guo ZQ, Zheng T, Chen B, Luo C, Ouyang S, Gong S, Li J, Mao LL, Lian F, Yang Y, Huang Y, Li L, Lu J, Zhang B, Zhou L, Ding H, Gao Z, Zhou L, Li G, Zhou R, Chen K, Liu J, Wen Y, Gong L, Ke Y, Yang SD, Qiu XB, Zhang N, Ren J, Zhong D, Yang CG, Liu J, Jiang H.Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer.Cancer Cell. 2016 Sep 12;30(3):474-484. doi: 10.1016/j.ccell.2016.08.003.

40. Xu Y, Liu X, Wang Y, Zhou N, Peng J, Gong L*, Ren J, Luo C, Luo X, Jiang H, Chen K, Zheng M*.Combinatorial Pharmacophore Modeling of Multidrug and Toxin Extrusion Transporter 1 Inhibitors: a Theoretical Perspective for Understanding Multiple Inhibitory Mechanisms.Sci Rep. 2015 Sep 2;5:13684. doi: 10.1038/srep13684.

41. Wang K, Feng C, Li C, Yao J, Xie X, Gong L, Luan Y, Xing G, Zhu X, Qi X, Ren J.Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor. Int J Mol Sci. 2015 Jul 20;16(7):16454-68. doi: 10.3390/ijms160716454.

42. Lu J, Peng J, Wang J, Shen Q, Bi Y, Gong L, Zheng M, Luo X, Zhu W, Jiang H, Chen K. Estimation of acute oral toxicity in rat using local lazy learning. J Cheminform. 2014 May 16;6:26. doi: 10.1186/1758-2946-6-26.

43. Yao J, Li CG, Gong LK, Feng CC, Li CZ, Gao M, Luan Y, Qi XM, Ren J.Hepatic cytochrome P450s play a major role in monocrotaline-induced renal toxicity in mice. Acta Pharmacol Sin. 2014 Feb;35(2):292-300. doi: 10.1038/aps.2013.145.

44. Xu Y, Liu X, Li S, Zhou N, Gong L, Luo C, Luo X, Zheng M, Jiang H, Chen K.Combinatorial pharmacophore modeling of organic cation transporter 2 (OCT2) inhibitors: insights into multiple inhibitory mechanisms. Mol Pharm. 2013 Dec 2;10(12):4611-9. doi: 10.1021/mp400423g.

45. Xie X, Miao L, Yao J, Feng C, Li C, Gao M, Liu M, Gong L, Wang Y, Qi X, Ren J.Role of multiple microRNAs in the sexually dimorphic expression of Cyp2b9 in mouse liver. Drug Metab Dispos. 2013 Oct;41(10):1732-7. doi: 10.1124/dmd.113.052217.

46. Xu Y, Shen Q, Liu X, Lu J, Li S, Luo C, Gong L*, Luo X*, Zheng M*, Jiang H. Computational Models for Predicting Interactions with Membrane Transporters. Current Medicinal Chemistry. 2013;20(16):2118-36.

47. Liu Y, Wang H, Cheng Y, Sun J, Qiao J, Lu H, Zhu L, Gong L, Ren J.A 26-week repeated-dose toxicity study of allisartan isoproxil in Sprague-Dawley rats. Drug Chem Toxicol. 2013 Oct;36(4):443-50. doi: 10.3109/01480545.2013.776580.

48. Qi XM, Miao LL, Cai Y, Gong LK*, Ren J*.ROS generated by CYP450, especially CYP2E1, mediate mitochondrial dysfunction induced by tetrandrine in rat hepatocytes. Acta Pharmacol Sin. 2013 Sep;34(9):1229-36. doi: 10.1038/aps.2013.62.

49. Liu X, Xue X, Gong LK, Qi XM, Wu YF, Xing GZ, Xiao Y, Luan Y, Wu XF, Li Y, Chen M, Miao LL, Yao J, Gu J, Lin DH, Ren J. 1H NMR-based metabolomic analysis of triptolide-induced toxicity in liver-specific cytochrome P450 reductase knockout mice. Metabolomics. 2012; 8(5):907-918.

50. Cheng Y, Liu Y, Wang H, Li J, Ren J, Zhu L*, Gong L*.A 26-week repeated dose toxicity study of Xian-ling-gu-bao in Sprague-Dawley rats. J Ethnopharmacol. 2013 Jan 9;145(1):85-93. doi: 10.1016/j.jep.2012.09.055. Epub 2012 Oct 30.

51. Wu M, Xing G, Qi X, Feng C, Liu M, Gong L, Luan Y, Ren J.Assessment of the mutagenic potential of arecoline in gpt delta transgenic mice. Mutat Res. 2012 Oct 9;748(1-2):65-9. doi: 10.1016/j.mrgentox.2012.07.001.

52. Luan Y, Xing G, Qi X, Wu M, Li C, Yao J, Gong L, Nohmi T, Gu J, Zhou W, Zheng S, Ren J.The application of hepatic P450 reductase null gpt delta mice in studying the role of hepatic P450 in genotoxic carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mutagenesis. Arch Toxicol. 2012 Nov;86(11):1753-61. doi: 10.1007/s00204-012-0891-6.

53. Wu Y, Qi X, Gong L, Xing G, Chen M, Miao L, Yao J, Suzuki T, Furihata C, Luan Y, Ren J.Identification of BC005512 as a DNA damage responsive murine endogenous retrovirus of GLN family involved in cell growth regulation. PLoS One. 2012;7(4):e35010. doi: 10.1371/journal.pone.0035010.

54. Xing G, Qi X, Chen M, Wu Y, Yao J, Gong L, Nohmi T, Luan Y, Ren J.Comparison of the mutagenicity of aristolochic acid I and aristolochic acid II in the gpt delta transgenic mouse kidney. Mutat Res. 2012 Mar 18;743(1-2):52-8. doi: 10.1016/j.mrgentox.2011.12.021.

55. Xue X#, Gong LK#, Maeda K, Luan Y, Qi XM, Sugiyama Y, Ren J. Critical role of organic anion transporters 1 and 3 in kidney accumulation and toxicity of aristolochic acid I. Mol Pharm. 2011 Dec 5;8(6):2183-92. doi: 10.1021/mp100418u.

56. Kotani N, Maeda K, Watanabe T, Hiramatsu M, Gong LK, Bi YA, Takezawa T, Kusuhara H, Sugiyama Y.Culture period-dependent changes in the uptake of transporter substrates in sandwich-cultured rat and human hepatocytes. Drug Metab Dispos. 2011 Sep;39(9):1503-10. doi: 10.1124/dmd.111.038968.

57. Chen M#, Gong L#, Qi X, Xing G, Luan Y, Wu Y, Xiao Y, Yao J, Li Y, Xue X, Pan G, Ren J. Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic acid I and attenuates its nephrotoxicity. Toxicol Sci. 2011 Aug;122(2):288-96. doi: 10.1093/toxsci/kfr138.

58. Xue X, Gong L*, Qi X, Wu Y, Xing G, Yao J, Luan Y, Xiao Y, Li Y, Wu X, Chen M, Gu J, Ren J*.Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity. Toxicol Lett. 2011 Aug 10;205(1):47-54. doi: 10.1016/j.toxlet.2011.05.003.

59. Li Y, Luan Y, Qi X, Li M, Gong L, Xue X, Wu X, Wu Y, Chen M, Xing G, Yao J, Ren J.Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II. Toxicol Sci. 2010 Dec;118(2):435-43. doi: 10.1093/toxsci/kfq282.

60. Xiao Y, Xue X, Wu YF, Xin GZ, Qian Y, Xie TP, Gong LK*, Ren J*.beta-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism. Acta Pharmacol Sin. 2009 Nov;30(11):1559-65. doi: 10.1038/aps.2009.156.

61. Yoshida, K., Maeda, K., Gong, L.-K., Hiramatsu, M., Takezawa, T., Sugiyama, Y. Evaluation of the contribution of the hepatic efflux transporters on the biliary excretion of drugs using sandwich-cultured rat hepatocytes. Japanese Pharmacology and Therapeutics, 2009; 37 (SUPPL. 1), pp. S53- 58. (in Japanese)

62. Wang B, Wang X, and Gong L. The construction of Williams design and randomization in cross-over clinical trials using SAS. Journal of Statistical Software, Code Snippets. 2009; 29:1-10.

63. Xue X, Xiao Y, Gong L, Guan S, Liu Y, Lu H, Qi X, Zhang Y, Li Y, Wu X, Ren J.Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice. J Ethnopharmacol. 2008 Sep 2;119(1):87-93. doi: 10.1016/j.jep.2008.05.037. Epub 2008 Jun 5.

64. Zhang Y, Qi X, Gong L, Li Y, Liu L, Xue X, Xiao Y, Wu X, Ren J.Roles of reactive oxygen species and MAP kinases in the primary rat hepatocytes death induced by toosendanin. Toxicology. 2008 Jul 10;249(1):62-8. doi: 10.1016/j.tox.2008.04.005. Epub 2008 Apr 16.

65. Liu LL, Gong LK, Wang H, Xiao Y, Wu XF, Zhang YH, Xue X, Qi XM, Ren J.Baicalin inhibits macrophage activation by lipopolysaccharide and protects mice from endotoxin shock. Biochem Pharmacol. 2008 Feb 15;75(4):914-22. doi: 10.1016/j.bcp.2007.10.009. Epub 2007 Dec 5.

66. Qi X, Cai Y, Gong L, Liu L, Chen F, Xiao Y, Wu X, Li Y, Xue X, Ren J.Role of mitochondrial permeability transition in human renal tubular epithelial cell death induced by aristolochic acid. Toxicol Appl Pharmacol. 2007 Jul 1;222(1):105-10. doi: 10.1016/j.taap.2007.03.029. Epub 2007 Apr 12.

67. Liu LL, Gong LK, Wang H, Xiao Y, Wu XF, Zhang YH, Xue X, Qi XM, Ren J.Baicalin protects mouse from Concanavalin A-induced liver injury through inhibition of cytokine production and hepatocyte apoptosis. Liver Int. 2007 May;27(4):582-91. doi: 10.1111/j.1478-3231.2007.01450.x.

68. Chen FP, Gong LK, Zhang L, Wang H, Qi XM, Wu XF, Xiao Y, Cai Y, Liu LL, Li XH, Ren J.Early lung injury contributes to lung fibrosis via AT1 receptor in rats. Acta Pharmacol Sin. 2007 Feb;28(2):227-37. doi: 10.1111/j.1745-7254.2007.00493.x.

69. Chen F, Gong L, Zhang L, Wang H, Qi X, Wu X, Xiao Y, Cai Y, Liu L, Li X, Ren J.Short courses of low dose dexamethasone delay bleomycin-induced lung fibrosis in rats. Eur J Pharmacol. 2006 May 1;536(3):287-95. doi: 10.1016/j.ejphar.2006.03.011. Epub 2006 Mar 14.

70. Ma D, Jiang Y, Chen F, Gong LK, Ding K, Xu Y, Wang R, Ge A, Ren J, Li J, Li J, Ye Q.Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. J Med Chem. 2006 Jan 26;49(2):456-8. doi: 10.1021/jm051101g.

71. Yan C, Xin-Ming Q, Li-Kun G, Lin-Lin L, Fang-Ping C, Ying X, Xiong-Fei W, Xiang-Hong L, Jin R.Tetrandrine-induced apoptosis in rat primary hepatocytes is initiated from mitochondria: caspases and endonuclease G (Endo G) pathway. Toxicology. 2006 Jan 20;218(1):1-12. doi: 10.1016/j.tox.2005.08.024.

72. Cai Y, Gong LK, Qi XM, Li XH, Ren J.Apoptosis initiated by carbon tetrachloride in mitochondria of rat primary cultured hepatocytes. Acta Pharmacol Sin. 2005 Aug;26(8):969-75. doi: 10.1111/j.1745-7254.2005.00143.x.

73. Liu LL, Gong LK, Qi XM, Cai Y, Wang H, Wu XF, Xiao Y, Ren J.Altered expression of cytochrome P450 and possible correlation with preneoplastic changes in early stage of rat hepatocarcinogenesis. Acta Pharmacol Sin. 2005 Jun;26(6):737-44. doi: 10.1111/j.1745-7254.2005.00737.x.

74. Gong LK, Li XH, Wang H, Zhang L, Chen FP, Cai Y, Qi XM, Liu LL, Liu YZ, Wu XF, Huang CG, Ren J.Effect of Feitai on bleomycin-induced pulmonary fibrosis in rats. J Ethnopharmacol. 2005 Jan 15;96(3):537-44. doi: 10.1016/j.jep.2004.09.046.

75. Gong LK, Li XH, Wang H, Zhang L, Cai Y, Qi XM, Liu LL, Liu YZ, Wu XF, Chen FP, Huang CG, Ren J.Feitai attenuates bleomycin-induced pulmonary fibrosis in rats. Biol Pharm Bull. 2004 May;27(5):634-40. doi: 10.1248/bpb.27.634.

76. Wang H, Liu YZ, Lu HL Sheng H, Du M, Wu JL, Gong LK, Ren J. Experimental pathological study on orally administration of Tx to rats (Abstr). Acta Pharmacologica Sinica, 2006 July, Supplement 1: 243

77. Liu YZ, Wang H, Gong LK, Du M, Wu JL, Wang MY, Lu HL, Sheng H, Li XH, Ren J. A Report of Oral Dose Toxicity Study of Triptolides (Tx) in Sprague-Dawley Rat (Abstr). Acta Pharmacologica Sinica, 2006 July, Supplement 1: 244

78. Liu LL, Gong LK, Cai Y, Xiao Y, Wang H, Ren J. The protective effect of Baicalin on Concavalin A-induced liver injury and the related mechanism (Abstr). Acta Pharmacologica Sinica, 2006 July, Supplement 1: 275

79. Qi XM, Cai Y, Xiao Y, Gong LK, Ren J. Aristolochic acid I targeted to adenine nucleotide translocase sensitizes mitochondrial permeability transition pore opening in vitro (Abstr). Acta Pharmacologica Sinica, 2006 July, Supplement 1: 295

80. Chen FP, Gong LK, Zhu DY and Ren J. DS1 delay lung fibrosis by withstanding HIF-1α (Abstr). Acta Pharmacologica Sinica, 2006 July, Supplement 1: 396

81. Gong LK, Chen FP, Zhang L, Qi XM, Wu XF, Xiao Y, Cai Y, Liu LL, Zhang YH, Wang H, Liu YZ, Li XH, Ren J. Role of hypoxia in bleomycin induced pulmonary fibrosis in rat (Abstr). Acta Pharmacologica Sinica, 2006 July, Supplement 1: 384

82. Cai Y, Qi XM, Gong LK, Ren J. Tetrandrine inhibits induction of the mitochondrial permeability transition: a possible mechanism for its protective effect of mitochondria (Abstr). Acta Pharmacologica Sinica, 2006 July, Supplement 1: 443.

83. Ren J, Cai Y, Gong LK, Qi XM, Liu LL, and Li XH. Mitochondria-initiated apoptosis in primary cultured rat hepatocytes by carbon tetrachloride (Abstr). Toxicology and Applied Pharmacology, 2004; 197: 293.

84. Gong LK, Cai Y, Qi XM, Liu LL, Li XH and Ren J. The effect of carbon tetrachloride on hepatocytes: cytotoxicity and related mechanisms in rat primary cultured hepatocytes (Abstr). Toxicology, 2003; 191(1): 40.

85. Liu LL, Qi XM, Gong LK, Cai Y and Ren J. Expression of microsomal cytochrome p450 (cyps) in medium-term bioassay for rat hepatocarcinogenesis (Abstr). Toxicology and Applied Pharmacology, 2004; 197: 179