全国同城凤凰楼信息茶楼_51pcmc品茶2024官网_全国兼职凤凰楼信息

Biography

Dr. Xiaoyan Chen is currently professor and principal investigator in Zhongshan Institute for Drug Discovery and Shanghai Institute of Materia Medica. Her research is focused on the chemistry and biology mechanisms of uncommon drug metabolism pathways, drug metabolism/transport responsible for DDIs and drug metabolism/transport in patients with hepatic/renal impairment. Dr. Chen serves on the committee member of Drug Metabolism Committee of Chinese Pharmacology Society, Pharmaceutical Analysis Committee of Chinese Pharmaceutical Association and Shanghai Pharmaceutical Association, etc. She is also a member of the Advisory Committee of Drug Registration and Evaluation of National Medical Products Administration. Dr. Chen has served as a principal investigator, conducting studies to evaluate preclinical and clinical ADME studies of new drug candidates. Among them, 27 innovative drugs have been approved by CFDA for marketing; more than 190 candidates have been approved to initiate human studies in China and in USA. She has published more than 180 SCI papers and has co-edited three books.

Research Directions

1. Drug Metabolism and Disposition.

2. Drug-Drug Interactions.

3. Pharmacokinetics in Special Populations.

Achievements

1. Research on the chemical and biological mechanisms of uncommon drug metabolism pathways

2. Research on the mechanisms of drug metabolism and transportation responsible for involved in the DDIs anf drug adverse reactions.

3. Influence of metabolic enzyme and transporter on pharamcokinetics in patient with hepatic or renal impairment

4. Drug metabolism and pharmacokinetics of new drug modalities (oligonucleotides, peptides,  carbohydrate-based drugs, proteolysis-targeting chimeras, antibody-drug conjugates, etc)

Publications

1. Guo ZT, Kong FD, Xie NJ, Chen ZD, Chen XY*. Mechanistic study on the effect of renal impairment on the pharmacokinetics of vildagliptin and its carboxylic acid metabolite. Pharmaceutical Research, 2022, https://doi.org/10.1007/s11095-022-03324-9

2. Pang XY, Tang CZ, Guo RC, Chen XY*. Non-cytochrome P450 enzymes involved in the oxidative metabolism of xenobiotics: Focus on the regulation of gene expression and enzyme activity. Pharmacology & Therapeutics. 2021, https://doi.org/10.1016/j.pharmthera.2021.108020

3. Liu L, Li W, Yang L, Guo ZT, Xue H, Xie NJ, Chen XY*. Effect of Itraconazole and Rifampicin as CYP3A Modulators but not P-gp Modulators on the Pharmacokinetics of Almonertinib and Active Metabolite HAS-719 in Healthy Volunteers. Acta Pharmacologica Sinica, 2021, 42: https://doi.org/10.1038/s41401-021-00710-8

4. Tang CZ, Pang XY, Guo ZT, Guo RC, Liu L, Chen XY*. Dual action of acidic microenvironment on the enrichment of the active metabolite of disulfiram in tumor tissues. Drug Metabolism and Disposition, 2021, 49:434–441

5. Liu L, Wang J, Xie C, Guo ZT, Hou XY, Xie NJ, Li J, Chen XY*. Drug interaction of ningetinib and gefitinib involving CYP1A1 and efflux transporters: consideration of high levels of the circulating metabolite. British Journal of Clinical Pharmacology, 2020, DOI: 10.1111/bcp.14621

6. Zhou L, Pang XY, Hou XY, Liu L, Guo ZT, Chen XY*. Increased Aldehyde Oxidase Activity of Human and Rat Caused by Nimesulide. Acta Pharmacologica Sinica, 2020, https://doi.org/10.1038/s41401-019-0336-3.

7. Kong FD, Pang XY, Zhao JH, Deng P, Zheng MY, Zhong D, Chen XY*. Hydrolytic metabolism of cyanopyrrolidine DPP-4 inhibitors mediated by dipeptidyl peptidases. Drug Metabolism and Disposition, 2019, 47: 238-248

8. Li XL, Sun JC, Guo ZT, Zhong DF, Chen XY*, Interplay between Carboxylesterase 2 and Intestine Transporters Limits the Bioavailability of Allisartan, a prodrug of Exp3174 for Hypertension Treatment in Humans. Drug Metabolism and Disposition, 2019, 47: 843–853

9. Hou XY, Zhou JL, Yu SD, Zhou L, Zhong DF, Chen XY*. Differences of the in vivo and in vitro metabolism of imrecoxib in humans: formation of rate-limiting aldehyde intermediate. Drug Metabolism and Disposition, 2018, 46: 1320-1328

10. Xu Y, Li L, Wang YL, Xing J, Zhou L, Zhong DF, Luo XM, Jiang HL, Chen KX, Zheng MY*, Deng P*, Chen XY*. Aldehyde oxidase mediated metabolism in drug-like molecules: a combined computational and experimental study. Journal of Medicinal Chemistry, 2017, 60: 2973-2982