全国同城凤凰楼信息茶楼_51pcmc品茶2024官网_全国兼职凤凰楼信息

Biography

09/2013-06/2017, Wuhan University, B.S., Pharmacy

09/2017-06/2022, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Ph.D., Pharmacology

07/2022-01/2023, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Assistant professor

02/2023-present, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Professor

Research Directions

1. Research on the Structure and function of hormone receptors;

2. Research on the biased signaling of G protein-coupled receptors (GPCRs) and biased drug discovery;

3. Research on the signaling transduction of chemosensors.

Achievements

2023, "Youth Talent Support Project" of the China Association for Science and Technology, Jia Duan

2022, Excellent Scientific Research Achievement Award of the female scientist in the China Biophysics Conference, the third prize, Jia Duan

2022, Ray Wu Prize for Excellence in Life Science Research, Ray Wu Memorial Fund, Jia Duan

2022, CAS Presidential Scholarship Award (Special First Class Prize), Jia Duan

2022, Excellent Graduate of Shanghai Municipality, Shanghai Municipality, Jia Duan

2021, National Graduate Student Scholarship, Jia Duan

2021, Women's Innovation "Future Star", Shanghai Municipality, Jia Duan

2021, Outstanding Women Award, Shanghai Municipality, Jia Duan

2021, Outstanding Graduate Student Award, CAS, Jia Duan

Publications

1. Jia Duan^#, Peiyu Xu^#, Xiaodong Luan^#, Yujie Ji, Xinheng He, Ning Song, Qingning Yuan, Ye Jin, Xi Cheng, Hualiang Jiang, Jie Zheng, Shuyang Zhang*, Yi Jiang*, H. Eric Xu*. Hormone- and antibody-mediated activation of the thyrotropin receptor. Nature. 2022 Sep; 609(7928): 854-859.

2. Jia Duan^#, Peiyu Xu^#, Xi Cheng^#, Chunyou Mao^#, Tristan Croll, Xinheng He, Jingjing Shi, Xiaodong Luan, Wanchao Yin, Erli You, Qiufeng Liu, Shuyang Zhang, Hualiang Jiang, Yan Zhang*, Yi Jiang*, H. Eric Xu*. Structures of full-length glycoprotein hormone receptor signaling complexes. Nature. 2021 Oct; 598 (7882): 688-692.

3. Jia Duan^#, Peiyu Xu^#, Huibing Zhang^#, Xiaodong Luan^#, Jiaqi Yang, Xinheng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shuyang Zhang*, Yan Zhang*, H. Eric Xu*. Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature Communications. 2023, 14, 519.

4. Jia Duan^#, Dan-Dan Shen^#, Tingting Zhao^#, Shimeng Guo^#, Xinheng He, Wanchao Yin, Peiyu Xu, Yujie Ji, Li-Nan Chen, Jinyu Liu, Huibing Zhang, Qiufeng Liu, Yi Shi, Xi Cheng, Hualiang Jiang, H. Eric Xu*, Yan Zhang*, Xin Xie*, Yi Jiang*. Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors. Nature Communications. 2022, 13, 1364.

5. Jia Duan^#, Qiufeng Liu^#, Qingning Yuan^#, Yujie Ji, Shengnan Zhu, Yangxia Tan, Xinheng He, Youwei Xu, Jingjing Shi, Xi Cheng, Hualiang Jiang, H. Eric Xu*, Yi Jiang*. Insights into divalent cation regulation and G13-coupling of orphan receptor GPR35.Cell Discovery. 2022 Dec 21;8(1):135.

6. Jia Duan^#, Dan-dan Shen^#, X. Edward Zhou^#, Peng Bi^#, Qiu-feng Liu, Yang-xia Tan, You-wen Zhuang, Hui-bing Zhang, Pei-yu Xu, Si-Jie Huang, Shan-shan Ma, Xin-heng He, Karsten Melcher, Yan Zhang*, H. Eric Xu*, Yi Jiang*. Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy. Nature Communications. 2020, 11, 4121.

7. Yujie Ji^#, Jia Duan^#,*, Qingning Yuan^#, Xinheng He, Gong Yang, Shengnan Zhu, Kai Wu, Wen Hu, Tianyu Gao, Xi Cheng, Hualiang Jiang, H. Eric Xu^#, Yi Jiang^#. Structural basis of ligand recognition selectivity of endothelin receptors. Nature Communications. Accepted. (^#, * Co-first and Co-corresponding author)

8. Qiufeng Liu^#, Dehua Yang^#, Youwen Zhuang^#, Tristan I. Croll, Xiaoqing Cai, Antao Dai, Xinheng He, Jia Duan, Wanchao Yin, Chenyu Ye, Fulai Zhou, Beili Wu, Qiang Zhao, H. Eric Xu*, Ming-Wei Wang*, Yi Jiang*. Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor. Nature Chemical Biology. 2021 Dec;17(12):1238-1244.

9. Xinheng He^#, Jia Duan, Yujie Ji, Lifen Zhao, Hualiang Jiang, Yi Jiang*, H. Eric Xu*, Xi Cheng*. Hinge Region Mediates Signal Transmission of Luteinizing Hormone and Chorionic Gonadotropin Receptor. Computational and Structural Biotechnology Journal. 2022, 20, 6503-6511.