全国同城凤凰楼信息茶楼_51pcmc品茶2024官网_全国兼职凤凰楼信息

Biography

09/1998-07/2002, Tsinghua University, B.S., Life Science

09/2002-01/2007, Tsinghua University, Ph.D., Biophysics

04/2007-07/2011, The Scripps Research Institute, Postdoctoral Fellow, Structural Biology

07/2011-present，Professor, Deputy Director， Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Research Directions

Structural Biology

Achievements

2014，Shu-Lan Medical Award for Young Scientist. Qiang Zhao

2015, Tanjiazhen Life Science Award. Qiang Zhao

2016, Outstanding Young Scientist Award of Chinese Academy of Sciences. Qiang Zhao

2016, China Youth Science and Technology Award. Qiang Zhao

2018, WuXi AppTec Life Chemistry Research Award Scholar Award. Qiang Zhao

2020, First Prize of Shanghai natural science award. Beili Wu, Qiang Zhao, Hualiang Jiang, Mingwei Wang, Hong Liu

Publications

1. Qiuxiang Tan#, Ya Zhu#, Jian Li, Zhuxi Chen, Gye Won Han, Irina Kufareva, Tingting Li, Limin Ma, Gustavo Fenalti, Jing Li, Wenru Zhang, Xin Xie, Huaiyu Yang, Hualiang Jiang, Vadim Cherezov, Hong Liu, Raymond C. Stevens, Qiang Zhao, Beili Wu*. Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science 341: 1387-1390, 2013

2. Kaihua Zhang#, Jin Zhang#, Zhan-Guo Gao, Dandan Zhang, Lan Zhu, Gye Won Han, Steven M. Moss, Silvia Paoletta, Evgeny Kiselev, Weizhen Lu, Gustavo Fenalti, Wenru Zhang, Christa E. Müller, Huaiyu Yang, Hualiang Jiang, Vadim Cherezov, Vsevolod Katritch, Kenneth A. Jacobson, Raymond C. Stevens, Beili Wu & Qiang Zhao*. Structure of the human P2Y12 receptor in complex with an antithrombotic drug. Nature 509: 115-118, 2014

3. Jin Zhang#, Kaihua Zhang#, Zhan-Guo Gao, Silvia Paoletta, Dandan Zhang, Gye Won Han, Tingting Li, Limin Ma,?Wenru Zhang, Christa E. Müller, Huaiyu Yang, Hualiang Jiang, Vadim Cherezov, Vsevolod Katritch, Kenneth A. Jacobson, Raymond C. Stevens, Beili Wu* & Qiang Zhao*. Agonist-bound structure of the human P2Y₁₂ receptor. Nature 509: 119-122, 2014  

4. Dandan Zhang, Zhan-Guo Gao, Kaihua Zhang, Evgeny Kiselev, Steven Crane, Jiang Wang, Silvia Paoletta, Cuiying Yi, Limin Ma, Wenru Zhang, Gye Won Han, Hong Liu, Vadim Cherezov, Vsevolod Katritch, Hualiang Jiang, Raymond C. Stevens, Kenneth A. Jacobson, Qiang Zhao* & Beili Wu*. Two disparate ligand binding sites in the human P2Y₁ receptor. Nature 520: 317-321, 2015. 

5. Kenneth A. Jacobson*, Silvia Paoletta, Vsevolod Katritch, Beili Wu, Zhan-Guo Gao, Qiang Zhao, Raymond C. Stevens, Evgeny Kiselev. Nucleotides Acting at P2Y Receptors: Connecting Structure and Function. Mol. Pharmacol. 88(2):220-230, 2015.

6. Dandan Zhang, Qiang Zhao, Beili Wu*. Structural Studies of G Protein-Coupled Receptors. Mol. Cells 38(10):836-842, 2015.

7. Tian Hua, Kiran Vemuri, Mengchen Pu, Lu Qu, Gye Won Han, Yiran Wu, Suwen Zhao, Wenqing Shui, Shanshan Li, Anisha Korde, Robert B. Laprairie, Edward L. Stahl, Jo-Hao Ho, Nikolai Zvonok, Han Zhou, Irina Kufareva, Beili Wu, Qiang Zhao, Michael A. Hanson, Laura M. Bohn*, Alexandros Makriyannis*, Raymond C. Stevens*, and Zhi-Jie Liu*. Crystal Structure of the Human Cannabinoid Receptor CB1. Cell 167:750-762, 2016.

8. Haonan Zhang#, Anna Qiao#, Dehua Yang#, Linlin Yang#, Antao Dai, Chris de Graaf, Steffen Reedtz-Runge, Venkatasubramanian Dharmarajan, Hui Zhang, Gye Won Han, Thomas D. Grant, Raymond G. Sierra, Uwe Weierstall, Garrett Nelson, Wei Liu, Yanhong Wu, Limin Ma, Xiaoqing Cai, Guangyao Lin, Xiaoai Wu, Zhi Geng, Yuhui Dong, Gaojie Song, Patrick R. Griffin, Jesper Lau, Vadim Cherezov, Huaiyu Yang, Michael A. Hanson, Raymond C. Stevens, Qiang Zhao, Hualiang Jiang*, Ming-Wei Wang* & Beili Wu*. Structure of the full-length glucagon class B G protein-coupled receptor. Nature 546(7657):259-264, 2017.

9. Haonan Zhang, Anna Qiao, Linlin Yang, Ned Van Eps, Klaus S. Frederiksen, Dehua Yang, Antao Dai, Xiaoqing Cai, Hui Zhang, Cuiying Yi, Can Cao, Lingli He, Huaiyu Yang, Jesper Lau, Oliver P. Ernst, Michael A. Hanson, Raymond C. Stevens, Ming-Wei Wang, Steffen Reedtz-Runge, Hualiang Jiang, Qiang Zhao* & Beili Wu*. Structure of the glucagon receptor in complex with a glucagon analogue. Nature 553:106-110, 2018.

10. Zhenlin Yang#, Shuo Han#, Max Keller#*, Anette Kaiser#, Brian J. Bender#, Mathias Bosse, Kerstin Burkert, Lisa M. K?gler, David Wifling, Guenther Bernhardt, Nicole Plank, Timo Littmann, Peter Schmidt, Cuiying Yi, Beibei Li, Sheng Ye, Rongguang Zhang, Bo Xu, Dan Larhammar, Raymond C. Stevens, Daniel Huster, Jens Meiler, Qiang Zhao, Annette G. Beck-Sickinger*, Armin Buschauer & Beili Wu*. Structural basis of ligand binding modes at the neuropeptide Y Y₁ receptor. Nature 556:520-524, 2018.

11. Can Cao#, Qiuxiang Tan#, Chanjuan Xu, Lingli He, Linlin Yang, Ye Zhou, Yiwei Zhou, Anna Qiao, Minmin Lu, Cuiying Yi, Gye Won Han, Xianping Wang, Xuemei Li, Huaiyu Yang, Zihe Rao, Hualiang Jiang, Yongfang Zhao, Jianfeng Liu, Raymond C. Stevens, Qiang Zhao, Xuejun C. Zhang* and Beili Wu*. Structural basis for signal recognition and transduction by platelet-activating-factor receptor. Nature Structural & Molecular Biology 25:488-495, 2018.

12. Hengxin Fan#, Shuanghong Chen#, Xiaojing Yuan, Shuo Han, Hui Zhang, Weiliang Xia, Yechun Xu, Qiang Zhao* and Beili Wu*. Structural basis for ligand recognition of the human thromboxane A2 receptor. Nature Chemical Biology 15:27-33, 2019.

13. Shuanghong Chen#, Mengjie Lu#, Dongsheng Liu#, Lingyun Yang, Cuiying Yi, Limin Ma, Hui Zhang, Qing Liu, Thomas M. Frimurer, Ming-Wei Wang, Thue W. Schwartz, Raymond C. Stevens, Beili Wu*, Kurt Wu?thrich* & Qiang Zhao*. Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography. Nature Communications 10:638, 2019.

14. Tong Chen#, Muya Xiong#, Xin Zong, Yunjun Ge, Hui Zhang, Mu Wang, Gye Won Han, Cuiying Yi, Limin Ma, Richard D. Ye, Yechun Xu*, Qiang Zhao* & Beili Wu*. Structural basis of ligand binding modes at the human formyl peptide receptor 2. Nature Communications 11(1):1208, 2020.

15. Anna Qiao#, Shuo Han#, Xinmei Li#, Zhixin Li#, Peishen Zhao#, Antao Dai, Rulve Chang, Linhua Tai, Qiuxiang Tan, Xiaojing Chu, Limin Ma, Thor Seneca Thorsen, Steffen Reedtz-Runge, Dehua Yang, Ming-Wei Wang, Patrick M. Sexton, Denise Wootten*, Fei Sun*, Qiang Zhao*, Beili Wu*. Structural basis of Gs and Gi recognition by the human glucagon receptor. Science 367(6484):1346-1352, 2020.

16. Tingting Tang#, Christin Hartig#, Qiuru Chen, Wenli Zhao, Anette Kaiser, Xuefeng Zhang, Hui Zhang, Honge Qu, Cuiying Yi, Limin Ma, Shuo Han, Qiang Zhao*, Annette G. Beck-Sickinger* & Beili Wu*. Structural basis for ligand recognition of the neuropeptide Y Y₂ receptor. Nature Communications 12:737, 2021.

17. Shuling Lin#, Shuo Han#, Xiaoqing Cai#, Qiuxiang Tan, Kexiu Zhou, Dejian Wang, Xinwei Wang, Juan Du, Cuiying Yi, Xiaojing Chu, Antao Dai, Yan Zhou, Yan Chen, Yu Zhou, Hong Liu, Jianfeng Liu, Dehua Yang, Ming-Wei Wang*, Qiang Zhao* & Beili Wu*. Structures of G_i-bound metabotropic glutamate receptors mGlu2 and mGlu4. Nature 594:583-588, 2021.

18. Juan Du#, Dejian Wang#, Hongcheng Fan#, Chanjuan Xu#, Linhua Tai#, Shuling Lin#, Shuo Han, Qiuxiang Tan, Xinwei Wang, Tuo Xu, Hui Zhang, Xiaojing Chu, Cuiying Yi, Peng Liu, Xiaomei Wang, Yu Zhou, Jean-Philippe Pin, Philippe Rondard, Hong Liu*, Jianfeng Liu*, Fei Sun*, Beili Wu* & Qiang Zhao*. Structures of human mGlu2 and mGlu7 homo- and heterodimers. Nature 594:589-593, 2021.

19. Hui Zhang^#, Kun Chen^#, Qiuxiang Tan^#, Qiang Shao^#, Shuo Han^#, Chenhui Zhang, Cuiying Yi, Xiaojing Chu, Ya Zhu*, Yechun Xu*, Qiang Zhao*, Beili Wu*. Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nature Communications 12:4151, 2021.

20. Xuefeng Zhang#, Chenglin He#, Mu Wang#, Qingtong Zhou#, Dehua Yang#, Ya Zhu#, Wenbo Feng, Hui Zhang, Antao Dai, Xiaojing Chu, Jia Wang, Zhenlin Yang, Yi Jiang, Ulrich Sensfuss, Qiuxiang Tan, Shuo Han, Steffen Reedtz-Runge, Eric H. Xu, Suwen Zhao*, Ming-Wei Wang*, Beili Wu*, Qiang Zhao*. Structures of the human cholecystokinin receptors in complex with agonists and antagonists. Nature Chemical Biology 17:1230-1237, 2021.

21. Ya Zhu#, Xiaowen Lin#, Xin Zong#, Shuo Han#, Mu Wang, Yuxuan Su, Limin Ma, Xiaojing Chu, Cuiying Yi, Qiang Zhao*, Beili Wu*. Structural basis of FPR2 in recognition of Ab₄₂ and neuroprotection by humanin. Nature Communications 13:1775, 2022.

22. Xiangli Qu#, Na Qiu#, Mu Wang#, Bingjie Zhang#, Juan Du, Zhiwei Zhong, Wei Xu, Xiaojing Chu, Limin Ma, Cuiying Yi, Shuo Han, Wenqing Shui*, Qiang Zhao* & Beili Wu*. Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1. Nature 604:779-785, 2022.

23. Tingting Tang#, Qiuxiang Tan#, Shuo Han#, Anne Diemar#, Kristin L?bner, Hongyu Wang, Corinna Schü?, Victoria Behr, Karin M?rl, Mu Wang, Xiaojing Chu, Cuiying Yi, Max Keller, Jacob Kofoed, Steffen Reedtz-Runge, Anette Kaiser*, Annette G. Beck-Sickinger*, Qiang Zhao* & Beili Wu*. Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors. Science Advances 8:eabm1232, 2022.

24. Ya Zhu#, Xiaowen Lin#, Xin Zong#, Shuo Han#, Mu Wang, Yuxuan Su, Limin Ma, Xiaojing Chu, Cuiying Yi, Qiang Zhao*, Beili Wu*.Structural basis of FPR2 in recognition of Aβ42 and neuroprotection by humanin. Nature Communications,13(1): 1775,2022.

25. Minmin Lu#, Wenli Zhao#, Shuo Han#, Xiaowen Lin, Tingyu Xu, Qiuxiang Tan, Mu Wang, Cuiying Yi, Xiaojing Chu, Weibo Yang, Ya Zhu* , Beili Wu* , Qiang Zhao*. Activation of the human chemokine receptor CX3CR1 regulated by cholesterol. Science Advances. 8(26):eabn8048，2022.