全国同城凤凰楼信息茶楼_51pcmc品茶2024官网_全国兼职凤凰楼信息

Biography

07/2022-Present

PI, Shanghai Institute of Materia Medica, ZhongShan Institute for Drug Discovery, Chinese Academy of Sciences.

03/2021-06/2022

Specialist in lung disease and regeneration, University of California, San Francisco (UCSF), US

03/2016-02/2021

Postdoc in lung disease and regeneration, UCSF

08/2012-12/2015

PhD in Biomedical Sciences, The Chinese University of Hong Kong (CUHK), Hong Kong

Research Directions

Lung injury and repair

Achievements

(1) Clarified the molecular pathogenesis of COPD/emphysema caused by alveolar mesenchymal hedgehog signaling activation (Journal of Clinical Investigation 2018);

(2) Mapped the publicly available single-cell Atlas of human COPD/emphysema (CellXGene);

(3) Demonstrated that human AEC2 loss and expansion of alveolar metaplastic basal cells in severe human lung injuries are causally connected through an AEC2-basal cell lineage trajectory driven by aberrant mesenchyme. (Nature Cell Biology 2022)

Publications

1. Kathiriya J^#, Wang C*^#, Zhou M, Brumwell A, Cassandras M, Saux C, Cohen M, Wang B, Wolters P, Matthay M, Kotton D, Chapman H*, and Peng T. (2022) Human alveolar Type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells. Nature Cell Biology, 24(1):10-23. (*corresponding & ^#first author)

2. Wang C, Mochel N, Christenson S, Cassandras M, Moon R, Brumwell A, Byrnes L, Li A, Yokosaki Y, Shan P, Sneddon J, Jablons D, Lee P, Matthay M, Chapman H and Peng T*. (2018) Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. The Journal of Clinical Investigation, 128(10):4343-58. (Recommended for The American Thoracic Society Webinar)

3. Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, and Peng T*. (2020) Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung. Nature Cell Biology, 22: 1295–1306. (Highlighted in Science Translational Medicine)

4. Mochel N, Krasilnikov M, Allen N, Lee J, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky A, Matthay M, Nakanishi M, Sheppard D, Campisi J, and Peng T*. (2022) Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung. Science, 378(6616):192-201.

5. Dahlgren M, Jones S, Cautivo K, Dubinin A, Farhat S, Carpena J, Yu K, Lee K, Wang C, Tward A, Krummel M, Molofsky A, Peng T, Molofsky A*. (2019) Adventitial stromal cells define group 2 innate lymphoid cell tissue niches. Immunity, 50: 1–16.

6. Wang C, Cassandras M, and Peng T*. (2019) The Role of Hedgehog Signaling in Adult Lung Regeneration and Maintenance. Journal of Developmental Biology. 2019, 7(3).

7. Wang C, Fok K, Tsang LL, Li F, Zhao A, Chan HC*, Chen H*. (2018) CD147 induces epithelial-to-mesenchymal transition by disassembling CAS/E-cadherin/β-catenin complex in human endometriosis. The American Journal of Pathology, 188(7):1597-1607 (Recommended by F1000Prime).

8. Wang C, Fok K, Cai Z, Chen H, Chan HC*. (2016) CD147 regulates extrinsic apoptosis in spermatocytes by modulating NFκB signaling pathways. Oncotarget, 8(2): 3132–3143.

9. Wang C, Jin A, Huang W, Tsang LL, Cai Z, Zhou X, Chen H*, Chan HC*. (2015) Upregulation of Bcl-2 by CD147 through ERK activation results in abnormal cell survival in human endometriosis. The Journal of Clinical Endocrinology and Metabolism, 100(7): E955-63 (Recommended by F1000Prime).

10. Jin A^#, Chen H^#, Wang C^#, Tsang LL, Jiang X, Cai Z, Chan HC*, Zhou X*. (2014) Elevated expression of CD147 in patients with endometriosis and its role in regulating apoptosis and migration of human endometrial cells. Fertility and Sterility, 101(6): 1681-7.

11. Wang C, Li X, Wang M, Qian J, Zheng K, Bian H, Han N, Wang J, Pan J, Zhu M*. (2014) Protective effects of ETC complex III and cytochrome c against hydrogen peroxide-induced apoptosis in yeast. Free Radical Research, 48(4): 435-44.

12. Chen H^#, Wang C^#, Gao Y, Gao J, Zhou X, Cai Z, Sun Q*. (2014) Generation of scFv specific to human VEGFR-3 from the neutralizing mAb BDD073. Protein Engineering, Design and Selection, 28(1): 19-22.

13. Yang Y, Jin H, Chen Y, Lin W, Wang C, Chen Z, Han N, Bian H, Zhu M, Wang J*. (2012) A chloroplast envelope membrane protein containing a putative LrgB Domain related to the control of bacterial death and lysis is required for chloroplast development in Arabidopsis thaliana. New Phytologist, 193(1): 81-95.

14. Li X, Qian J, Wang C, Zheng K, Ye L, Fu Y, Han N, Bian H, Pan J, Wang J, Zhu M*. (2011) Regulating cytoplasmic calcium homeostasis can reduce aluminum toxicity in yeast. Plos One, 6(6): e21148.