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Biography

Education 
Sep.2016-Dec.2019 Ph.D. in Pharmaceutics, China Pharmaceutical University
Sep.2013-Jun.2016 M.S. in Pharmaceutics, China Pharmaceutical University

Sep.2009-Jun.2013 B.S. in Pharmaceutic Preparation, China Pharmaceutical University

Work Experience
Oct.2022-present Research Associate/Youth PI in ZhongShan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Jan.2020-Oct.2022 Postdoctoral Research Fellow in China Pharmaceutical University

Research Directions

1. Targeted drug delivery and smart drug release systems

2. Immunomodulatory drug delivery systems

3. Advanced and innovative drug formulations

Achievements

Dr. Shiyang Shen dedicated to designing effective drug delivery systems and medicinal functional materials, exploring their related applications and specific mechanisms in the treatment against serious diseases, especially focusing on developing intelligent strategies to overcome the drug resistance in malignant tumors. He published several research articles in high-level international journals such as Nature Nanotechnology and Nano Letters as first author, which average impact factor is 18. In addition to applying for two invention patents, he hosted five scientific research projects, including the National Natural Science Foundation of China for Young Scholars and Special Funding of China Postdoctoral Science Fund.

Publications

(1) Shiyang Shen^#; Teng Li^#; Jinyi Fan; Quanlin Shao; He Dong; Xiao Xu; Ran Mo^*. Lipid-polymer hybrid nanoparticle with cell-distinct drug release for combination cancer treatment. Acta Pharmaceutica Sinica B, 2022, In press.

(2) Shiyang Shen^#; Shiqi Lin^#; Yuying Chen; Ying Zhang; Yingjiao He; Xiao Xu; Yang Feng; Yougong Lu; Ran Mo^*. Combating cancer stem-like cell-derived resistance to anticancer protein by liposome-mediated acclimatization strategy. Nano Letters, 2022, 22(6), 2419-2428.

(3) Shiyang Shen; Xiao Xu; Shiqi Lin; Ying Zhang; Huayu Liu; Can Zhang; Ran Mo^*. A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stem-like cells. Nature Nanotechnology, 2021, 16(1), 104-113. 

(4) Shiyang Shen^#; Li Zhang^#; Mengru Li; Zhizi Feng; Huixia Li; Xiao Xu; Shiqi Lin; Ping Li; Can Zhang; Xiaojun Xu^*; Ran Mo^*. Collaborative assembly-mediated siRNA delivery for relieving inflammation-induced insulin resistance. Nano Research, 2020, 13(11), 2958-2966.

(5) Meng Liu^#; Shiyang Shen^#; Di Wen; Mengru Li; Teng Li; Xiaojie Chen; Zhen Gu^*; Ran Mo^*. Hierarchical nanoassemblies-assisted combinational delivery of cytotoxic protein and antibiotic for cancer treatment. Nano Letters, 2018, 18(4), 2294-2303.

(6) Shiyang Shen; Meng Liu; Teng Li; Shiqi Lin; Ran Mo^*. Recent progress in nanomedicine-based combination cancer therapy using a site-specific co-delivery strategy. Biomaterials Science, 2017, 5(8), 1367-1381.  

(7) Xiao Xu; Xuechao Huang; Ying Zhang; Shiyang Shen; Zhizi Feng; He Dong; Can Zhang; Ran Mo^*. Self-regulated hirudin delivery for anticoagulant therapy. Science Advances, 2020, 6(41), eabc0382.

(8) Haojie Wang^#; Xiao Xu^#; Xin Guan; Shiyang Shen; Xuechao Huang; Guoyin Kai; Shunyi Zhao; Wenchen Ruan; Luyong Zhang; Tao Pang^*; Ran Mo^*. Liposomal 9-aminoacridine for treatment of ischemic stroke: From drug discovery to drug delivery. Nano Letters, 2020, 20(3), 1542-1551.

(9) Xiao Xu^#; Teng Li^#; Shiyang Shen; Jinqiang Wang; Peter Abdou; Zhen Gu^*; Ran Mo^*. Advances in engineering cells for cancer immunotherapy. Theranostics, 2019, 9(25), 7889-7905.

(10) Tianyue Jiang; Shiyang Shen; Tong Wang; Mengru Li; Bingfang He^*; Ran Mo^*. A substrate-selective enzyme-catalysis assembly strategy for oligopeptide hydrogel-assisted combinatorial protein delivery. Nano Letters, 2017, 17(12), 7447-7454.

(11) Jingwei Xue; Zekai Zhao; Lei Zhang; Lingjing Xue; Shiyang Shen; Yajing Wen; Zhuoyuan Wei; Lu Wang; Lingyi Kong; Hongbin Sun; Qineng Ping; Ran Mo^*; Can Zhang^*. Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence. Nature Nanotechnology, 2017, 12(7), 692-700.