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Biography

Dr. Aijun Qiao was graduated with his PhD degree in Biochemistry and Molecular Biology from Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Tsinghua University in China, and received his postdoctoral training from Feinberg Cardiovascular Research Institute, School of Medicine, Northwestern University at Chicago and Cancer Center of Augusta University at Augusta, respectively. After postdoctoral training, he joined the Department of Biomedical Engineering at the University of Alabama at Birmingham as Assistant Professor in June 2017. From September 2022, he joined Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences as Professor.

Dr. Qiao has broad research experiences in Metabolic diseases and cardiovascular diseases, including Obesity, Type 2 diabetes (T2D), Non-alcohol fatty liver disease (NAFLD), Insulin resistance, Dyslipidemia and Atherosclerosis. His research mainly focuses on studying the molecular and pathological mechanism of these diseases and identifying novel therapeutic targets for drug development. Dr. Qiao has published over 34 original research articles which some are in top journals, such as Hepatology, Nature Communications, The Journal of Cell Biology, et al. He is reserving an editor board members and professional reviewers for numerous Journals. 

Research Directions

1. Identifying novel therapeutic targets for metabolic diseases, including Obesity, T2D and NAFLD;

2. Identifying and screen small molecules and chemicals for anti-diabetes;

3. Investigating the signaling networks between heart and fat contributing to the development and progress of cardiovascular diseases.

Achievements

1. Identified novel mechanisms underlying hepatic metabolic disorders, including nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) (J. Hepatol., 2013; Hepatology, 2011; FEBS Lett., 2010; Diabetologia, 2016; Front Physiol, 2022);

2. Identified novel mechanisms of mitochondrial biogenesis and oxidation and their relevance to the pathogenesis of metabolic disorders (Mol. Cell. Biol., 2018; J. Cell Biol., 2017 [Selected as a spotlight paper by the journal and highlighted by an editorial comment]; Mitochondrion, 2010; Biochem J., 2010);

3. Uncovered novel mechanisms and therapeutic strategies contributing to the ischemia heart diseases (IHD) and heart failure (J. Am. Heart Assoc., 2013; Theranostics, 2020; Cardiol Cardiovasc Med, 2021; Theranostics, 2021; Front Bioeng Biotechnol, 2022; Cardiovasc Res, 2022);

4. Revealed a novel role of Sam68 in hepatic gluconeogenesis, adipose thermogenesis, and vascular   biology regulation (J. Mol. Cell. Cardiol., 2019; Nat. Commun., 2021; FASEB J, 2021; Int J Mol Sci, 2022; in revision for publication in Circ. Res, 2022). 

Publications

1. Aijun Qiao*, Wenxia Ma, Ying Jiang, Chaoshan Han, Baolong Yan, Junlan Zhou, Gangjian Qin*. Hepatic Sam68 regulates systemic glucose homeostasis and insulin sensitivity. International Journal of Molecular Sciences. 2022, 23(19), 11469. doi.org/10.3390/ijms231911469. (*Corresponding author)

2. Huabing Zhang*, Guang Ren*, Aijun Qiao*. Editorial: Hepatic Glucose and Lipid Metabolism. Frontiers in Physiology, section Metabolic Physiology. 2022, 13:1009566. doi.org/10.3389/fphys.2022.1009566. (*Corresponding author)

3. Asher Kahn-Krell, Danielle Pretorius, Bijay Guragain, Xi Lou, Yuhua Wei, Jianhua Zhang, Aijun Qiao, Yuji Nakada, Timothy J. Kamp, Lei Ye, Jianyi Zhang. A Three-Dimensional Culture System for Generating Cardiac Organoids Composed of Cardiomyocytes, Endothelial Cells, Smooth-Muscle Cells, and Cardiac Fibroblasts Derived from Human Induced-Pluripotent Stem Cells. Frontiers in Bioengineering and Biotechnology，2022; 10: 908848. doi.org/10.3389/fbioe.2022.908848.

4. Aijun Qiao*, Wenxia Ma, Jianxin Deng, Junlan Zhou, Chaoshan Han, Eric Zhang, Chan Boriboun, Shiyue Xu, Chunxiang Zhang, Chunfa Jie, Jeong-a Kim, Kirk Habegger, Hongyu Qiu, Ting C Zhao, Jianyi Zhang, Gangjian Qin*. Ablation of Sam68 in adult mice increases thermogenesis and energy expenditure. The FASEB Journal, 2021, 35(8): e21772. doi:10.1096/fj.202100021R. (*Corresponding author)

5. Aijun Qiao, Junlan Zhou, Shiyue Xu, Wenxia Ma, Chan Boriboun, Teayoun Kim, Baolong Yan, Jianxin Deng, Liu Yang, Eric Zhang, Yuhua Song, Yongchao C. Ma, Stephane Richard, Chunxiang Zhang, Hongyu Qiu, Kirk Habegger, Jianyi Zhang, Gangjian Qin. Sam68 promotes hepatic gluconeogenesis via CRTC2. Nature Communications, 2021, 12(1):3340. doi.org/10.1038/s41467-021-23624-9.

6. Aijun Qiao#, Xiongjie Jin#, Junfeng Pang, Demetrius Moskophidis, and Nahid F. Mivechi. The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis. Journal of Cell Biology, 2017, 216:723-741. doi.org/10.1083/jcb.201607091. (#Co-first author)

7. Aijun Qiao, Arineh Khechaduri, R. Kannan Mutharasan, Rongxue Wu, Varun Nagpal and Hossein Ardehali. MicroRNA-210 Decreases Heme Levels by Targeting Ferrochelatase in Cardiomyocyte. Journal of the American Heart Association, 2013, 2(2): e000121. doi: 10.1161/JAHA.113.000121.

8. Aijun Qiao, Jichao Liang, Yaojun Ke, Chenghong Li, Ying Cui, Lian Shen, Huabing Zhang, Anfang Cui, Xiaojun Liu, Changzheng Liu, Yong Chen, Yi Zhu, Youfei Guan, Fude Fang, Yongsheng Chang. Mouse PNPLA3 Influences Systemic Lipid and Glucose Homeostasis. Hepatology, 2011, Aug; 54(2): 509-21. doi: 10.1002/hep.24402.

9. Xiaojun Liu#, Aijun Qiao#, Yaojun Ke, Xingxing Kong, Jichao Liang, Rui Wang, XiaoqingOuyang, Jin Zuo, Yongsheng Chang, Fude fang. FoxO1 Represses LXRα-Mediated Transcriptional Activity of SREBP-1c Promoter in HepG2 Cells. FEBS Lett, 2010, 20(584): 4330-4334. doi: 10.1016/j.febslet.2010.09.027. (#Co-first author)

10. Aijun Qiao, Wenxia Ma, Daquan Li, Qingmei Meng. The Sex Identification of Earlier Embryos from Generic Hybrids of Chicken-Quail by Wpkci. Scientia Agricultura Sinica, 2008, 7(4): 497-501. doi.org/10.1016/S1671-2927(08)60094-2 .

11. Chaoshan Han, Junjie Yang, Eric Zhang, Ying Jiang, Aijun Qiao, Qinkun Zhang, Hind Lal, Prasanna Krishnamurthy, Jianyi Zhang, Gangjian Qin. Metabolic labeling of cardiomyocyte-derived exosomal miRNAs identifies miR-208a in cardiac regulation of lung gene expression. Journal of Extracellular Vesicles, 2022, 11(10): e12246.

12. Xi Lou, Yawen Tang, Lei Ye, Danielle Pretorius, Vladimir G. Fast, Asher M Kahn-Krell, Jue Zhang, Jianhua Zhang, Aijun Qiao, Gangjian Qin, Timothy Kamp, James A. Thomson, Jianyi Zhang. Cardiac muscle patches containing four types of cardiac cells derived from human pluripotent stem cells improve recovery from cardiac injury in mice. Cardiovascular Research, 2022. (Accepted)

13. Weiwei Sun#, Xiumei Yan#, Aijun Qiao, Yuanjiao Zhang, Ling Yang, Huicong Huang, Hongfei Shi and Baolong Yan. Upregulated galectin-1 in Angiostrongylus cantonensis L5 reduces body fat and increases oxidative stress tolerance. Parasites & Vectors, 2022, 15(1):46. doi: 10.1186/s13071-022-05171-4. (#Co-first author)

14. Sini Sunny, Anil Kumar Challa, Aijun Qiao, Arun Jyothidasan, Prasanna Krishnamurthy, Muralidharan T Ramamurthy, David K Crossman, Steven Pogwizd, Senthilkumar Cinghu, Namakkal S Rajasekaran. Transcriptional Regulation of structural and functional adaptations in a developing adulthood myocardium. Cardiology and Cardiovascular Medicine, 2021, 5(5): 454-470. doi: 10.26502/fccm.92920215.

15. Liu Yang, Jianxin Deng, Wenxia Ma, Aijun Qiao, Shiyue Xu, Chan Boriboun, Xiang Kang, Yang Yu, Dunzheng Han, Patrick Ernst, Lufang Zhou, Jiawei Shi, Eric Zhang, Min Cheng, Kai Huang, Hongyu Qiu, Shinichi Nakagawa, Seth Blackshaw, Jianyi Zhang, Gangjian Qin. The long non-coding RNA myocardial infarct associate transcript (MIAT) aggravates cardiac hypertrophy and heart failure. Theranostics, 2021, 11(16):7995-8007. doi: 10.7150/thno.50990.

16. Dunzheng Han#, Junjie Yang#, Eric Zhang, Yanwen Liu, Chan Boriboun, Aijun Qiao, Yang Yu, Shiyue Xu, Liu Yang, Wenying Yan, Bihui Luo, Dongfeng Lu, Chunxiang Zhang, Jianyi Zhang, Gangjian Qin. Analysis of mesenchymal stem cell proteomes in situ in the ischemic heart. Theranostics, 2020, 10(24):11324-11338. doi: 10.7150/thno.47893.(#Co-first author)

17. Shuling Han#, Shiyue Xu#, Junlan Zhou, Aijun Qiao, Chan Boriboun, Wenxia Ma, Huadong Li, Dauren Biyashev, Liu Yang, Eric Zhang, Qinghua Liu, Shayi Jiang, Ting C Zhao, Prasanna Krishnamurthy, Chunxiang Zhang, Stéphane Richard, Hongyu Qiu, Jianyi Zhang, Gangjian Qin. Sam68 impedes the recovery of arterial injury by augmenting inflammatory response. Journal of Molecular and Cellular Cardiology, 2019, 137:82-92. doi: 10.1016/j.yjmcc.2019.10. (#Co-first author)

18. Xiongjie Jin, Aijun Qiao, Demetrius Moskophidis, and Nahid F. Mivechi. Modulation of HSF1 activity through silencing of ser303/ser307 phosphorylation supports a metabolic program leading to age-related obesity and insulin resistance. Molecular and Cellular Biology, 2018, 38: e00095-18. doi: 10.1128/MCB.00095-18.

19. Ying Cui, Aijun Qiao, Tao Jiao, Huabing Zhang, Yuan Xue, Yongkang Zou, Anfang Cui, Fude Fang, and Yongsheng Chang. The hepatic FOXQ1 transcription factor regulates glucose metabolism in mice. Diabetologia, 2016, 59:2229-39. doi: 10.1007/s00125-016-4043-z.

20. Jichao Liang#, Changzheng Liu#, Aijun Qiao, Ying Cui, Huabing Zhang, Anfang Cui, Shutian Zhang, Yanli Yang, Xinhua Xiao, Yong Chen, Fude Fang, Yongsheng Chang. MicroRNA-29a-c decrease fasting blood glucose levels by negatively regulating hepatic gluconeogenesis. Journal of Hepatology, 2013, 58(3):535-42. doi: 10.1016/j.jhep.2012.10.024. (#Co-first author)

21. Liuluan Zhu, Yaojun Ke, Di Shao, Ying Cui, Aijun Qiao, Nishith Gupta, Yongsheng Chang and Fude Fang. PPARγ co-activator-1α co-activates steroidogenic factor 1 to stimulate the synthesis of luteinizing hormone and aldosterone. Biochemical J, 2010, 432(3): 473-483. doi: 10.1042/BJ20100460.

22. Di Shao, Yang Liu, Xiaojun Liu, Liuluan Zhu, Ying Cui, Anfang Cui, Aijun Qiao, Xingxing Kong, Yong Liu, Quan Chen, Nishith Gupta, Fude Fang, Yongsheng Chang. PGC-1 beta-regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERR alpha. Mitochondrion, 2010, 5(10): 516-527. doi: 10.1016/j.mito.2010.05.012.

Aijun Qiao, Wenxia Ma, Daquan Li, Qingmei Meng. The Sex Identification of Earlier Embryos from Generic Hybrids of Chicken-Quail by Wpkci. Scientia Agricultura Sinica, 2008, 7(4): 497-501. doi:10.1016/S1671-2927(08)60094-2.