- Your location:Home > Education > Supervisor > Medicinal Chemistry
Name：Qiang Liu 刘强 Title：Principal Investigator Education：Ph.D Contact Number：0760-85286866 E-mail：liuqiang@simm.ac.cn Address：SSIP Healthcare and Medicine Demonstration Zone, Zhongshan Tsuihang New District, Guangdong 528400
-
Biography
Dr. Liu obtained his bachelor degree at Jining Medical College, China in 2012 before he went to Sichuan University to pursue his Master degree in Medicinal Chemistry. In 2015, Dr Liu was sponsor by CSC (Chinese Scholarship Council) to study chemistry at Leiden University. After 4 years Ph.D study, Dr Liu went to Complex of Carbohydrate Research Center to continue his research Carbohydrate Chemistry. From Feb. 2022, he started his own research group in SIMM, China as an independent PI focusing on the development of new carbohydrate drugs and vaccines.
-
Research Directions
Carbohydate Chemistry, Carbohydrate drugs
-
Achievements
-
Publications
1. Liu Q, Kistemaker HAV, Bhogaraju S, Dikic I, Overkleeft HS, van der Marel GA, Ovaa H, van der Heden van Noort GJ,* Filippov DV.* A General Approach Towards Triazole-Linked Adenosine Diphosphate Ribosylated Peptides and Proteins. Angew Chem Int Ed Engl 2018, 57 (6), 1659-1662.
2. Liu Q, Knobloch G, Voorneveld J, Meeuwenoord NJ, Overkleeft HS, van der Marel GA, Andreas G. Ladurner AG,* Filippov DV.* Chemical Synthesis of Linear ADP-ribose Oligomers up to Pentamer and their Binding to the Oncogenic Helicase ALC1. Chem. Sci. 2021, 12 (37), 12468.
3. Liu Q, Kistemaker HAV, Overkleeft HS, van der Marel GA, Filippov DV.* Synthesis of ribosyl-ribosyl-adenosine-5 ',5 '',5'''(triphosphate)-the naturally occurring branched fragment of poly(ADP ribose). Chem. Commun. 2017, 53 (74), 10255-10258
4. Kliza KW#*, Liu Q#, Roosenboom LWM, Jansen PWTC, Filippov DV,* Vermeulen M.* Reading ADP-ribosylation signalling using chemical biology and interaction proteomics. Mol. Cell 2021, 81 (21), 4552-4567. 他引：
5. Rack JGM#, Liu Q#, Zorzini V, Voorneveld J, Ariza A, Honarmand Ebrahimi K, Reber JM, Krassnig SC, Ahel D, van der Marel GA, Mangerich A, McCullagh JSO, Filippov DV,* Ahel I.* Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal. Nat Commun 2021,12 (1), 4581-4594.
6. Liu Q, Florea BI, Filippov DV.* ADP-Ribosylati on Goes Normal: Serine as the Major Site of the Modification. Cell Chem Biol 2017, 24 (4), 431-432.
7. Liu Q#, Qiang X#, Li Y, Sang Z, Li Y, Tan Z, Deng Y. Design, synthesis and evaluation of chromone-2-carboxamido-alkylbenzylamines as multifunctional agents for the treatment of Alzheimer’s disease. Bioorg. Med. Chem. 2015, 23 (5), 911-923.
8. Liu Q, van der Marel GA, Filippov DV. Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose. Org Biomol Chem 2019. 17(22), 5460-5474.
9. Voorneveld J, Rack JGM, van Gijlswijk L, Meeuwenoord NJ, Liu Q, Overkleeft HS, van der Marel GA, Ahel I, Filippov DV. Molecular Tools for the Study of ADP-Ribosylation: A Unified and Versatile Method to Synthesise Native Mono-ADP-Ribosylated Peptides. Chem. Eur. J. 2021, 27 (41), 10621-10627.
10. Qiang XM, Sang ZP, Yuan W, Li Y, Liu Q, Bai P, Shi YK, Tan ZH, Deng Y. Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease. Eur. J. Med. Chem. 2014, 76, 314-331.