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Biography

Prof. Jia Li graduated from the Department of Pharmacy, Zhejiang Medical University in 1992. He did his postgraduate training at the Shanghai Institute of Materia Medica Chinese Academy of Sciences since 1994 and obtained the doctorate of science in 2000.

Research Directions

Innovative drug discovery and evaluation; Drug mechanism of action and new target; Chemicobiology in cell recognition and cell fate regulation

Achievements

Prof. Li has led 20 undergoing pre-clinical studies. Twelve drug candidates have been successfully transferred to domestic pharmaceutical companies. Eight drug candidates entered phase I clinical trial.  Prof Li is the co-inventor of 227 patents (with 153 already issued). Prof. Li has published 506 SCI papers, >10000 total citations. Prof Li has been supported by the National Science Foundation for Distinguished Young Scholars, selected as one of the leading talents in Science and Technology innovation of the National Project of Tens of Millions of Talents, National Young and Middle-aged Leading Talents in Science and Technology Innovation, and National "Ten Thousand Talents Plan" leading Talents in science and technology innovation. Prof. Li has won the China Youth Science and Technology Award, the second prize of national Science and Technology Progress, and the first prize of Shanghai Science and Technology Progress.

Publications

1. SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target. Xia B, Shen X, He Y, Pan X, Liu FL, Wang Y, Yang F, Fang S, Wu Y, Duan Z, Zuo X, Xie Z, Jiang X, Xu L, Chi H, Li S, Meng Q, Zhou H, Zhou Y, Cheng X, Xin X, Jin L, Zhang HL, Yu DD, Li MH, Feng XL, Chen J, Jiang H, Xiao G, Zheng YT*, Zhang LK*, Shen J*, Li J*, Gao Z*. Cell Res. 2021, 31(8):847-860

2.   AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ. Jiang Y, Dong Y, Luo Y, Jiang S, Meng FL, Tan M, Li J*, Zang Y*. Cell Rep. 2021, 34(7):108713

3. Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans. Wu L, Xia M, Duan Y, Zhang L, Jiang H, Hu X, Yan H, Zhang Y, Gu Y, Shi H, Li J*, Gao X*, Li JY*. Cell Death Dis. 2019, 10(6):468

4.    Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex. Zhang Y, Kong Y, Guo H, Liu Y, Zang Y*, Li J*. J Mol Cell Biol. 2022, 14(3):mjac017

5. AMPK regulates anaphase central spindle length by phosphorylation of KIF4A. Li QR, Yan XM, Guo L*, Li J*, Zang Y*. J Mol Cell Biol 2018, 10(1):2-17

6. PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way. Yu X, Long Y, Chen B, Tong Y, Shan M, Jia X, Hu C, Liu M, Zhou J, Tang F, Lu H, Chen R, Xu P, Huang W, Ren J, Wan Y, Sun J, Li J*, Jin G*, Gong L*. J Immunother Cancer. 2022 Oct;10(10):e004590

7. Discovery of 4-cyclopropyl-3-(2-((1-cyclopropyl-1H-pyrazol-4-yl) amino) quinazolin-6-yl)-N-(3-(trifluoromethyl) phenyl) benzamides as potent discoidin domain receptor inhibitors for the treatment of idiopathic pulmonary fibrosis. Wang Q, Tang B, Sun D, Dong Y, Ji Y, Shi H, Zhou L, Yang Y, Luo M, Tan Q, Chen L, Dong Y, Li C, Xie R, Zang Y, Shen J, Xiong B, Li J*, Chen D*. Acta Pharm Sin B. 2022, 12(4):1943-1962

8. Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia Via Promoting Glucose Oxidation. Jiang H, Jin J, Duan Y, Xie Z, Li Y, Gao A, Gu M, Zhang X, Peng C, Xia C, Dong T, Li H, Yu L, Tang J, Yang F*, Li JY*, Li J*. Diabetes 2019, 68(12):2197-2209

9. DOT1L regulates thermogenic adipocyte differentiation and function via modulating H3K79 methylation. Shuai L, Li BH, Jiang HW, Yang L, Li J*, Li JY*. Diabetes 2021, 70(6):1317-1333

10. Small-molecule fluorescence-based probes for interrogating major organ diseases. Han HH, Tian H Jr, Zang Y, Sedgwick AC, Li J*, Sessler JL*, He XP,* James TD*. Chem Soc Rev. 2021, 50 (17):9391-9429

11. Fluorescent probes for the imaging of lipid droplets in live cells. Tian H, Sedgwick AC, Han HH, Sen S, Chen GR, Zang Y, Sessler JL, James TD*, Li J*, He XP*. Coord. Chem. Rev. 2021, 427, 213577

12. SIRT5 Regulates Brown Adipocyte Differentiation and Browning of Subcutaneous White Adipose Tissue. Shuai L, Zhang LN, Li BH, Tang CL, Wu LY, Li J*, Li JY*. Diabetes. 2019, 68(7):1449-1461

13. Fluorescent probes for the detection of disease-associated biomarkers. Dou WT, Han HH, Sedgwick AC, Zhu GB, Zang Y, Yang XR*, Yoon J*, James TD*, Li J*, He XP*. Sci Bull 2022, 67(8):853-78