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Name：Zhenghui Kang 康正辉 Title：Principal Investigator Education：Ph.D Contact Number：0760-85286866 E-mail：kangzhenghui@simm.ac.cn Address：SSIP Healthcare and Medicine Demonstration Zone, Zhongshan Tsuihang New District, Guangdong 528400
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Biography
Dr. Zhenghui Kang received his B.S. in chemistry from Anhui Normal University (2013) and Ph.D. in organic chemistry from East China Normal University under the guidance of Professor Wenhao Hu (2018). Then, Kang became a postdoctoral fellow at Sun Yat-sen University with Professor Xinfang Xu and Wenhao Hu during 2018-2022. In 2022 Dr. Kang joined Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences (CAS) and Zhongshan Institute for Drug Discovery as associate professor.
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Research Directions
1. Medicinal Chemistry: Hit generation and lead optimization based on the new synthetic method. Design and synthesis of "medicinal lead compounds" with both biological activity and medicinal properties for clinical needs such as tumors and metabolic diseases.
2. Organic Chemistry: Development of useful new synthetic reactions and asymmetric catalysis strategy for rapidly construction of structurally diversified compounds with potential medicinal skeleton.
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Achievements
Development of a series of novel multi-component reactions (MCRs) via trapping of transient intermediates that derived from metal carbenoid with various electrophiles. realized the excellent stereocontrol of the reactions by discovery of the new asymmetric synergistic catalysis strategy. The efficient synthetic approach was employed for the rapid and efficient construction of chiral polyfunctional molecules, which can be used to build the library of new compounds for drug discovery. He has published over 20 research papers in international journals, including Journal of the American Chemical Society, Nature Communications, CCS Chem., Org. Lett., Chem. Commun. The research proposals have got funded by Natural science foundation of China (NSCF), including “National Natural Science Foundation of China”, “Natural Science Foundation of Guangdong Province, China” and “The First-Rate China Postdoctoral Science Foundation”.
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Publications
1. Zhenghui Kang,# Wenju Chang,# Xue Tian, Xiang Fu, Wenxuan Zhao, Xinfang Xu,* Yong Liang,* Wenhao Hu* Ternary Catalysis Enabled Three-component Asymmetric Allylic Alkylation as a Concise Track to Chiral α,α-Disubstituted Ketones. J. Am. Chem. Soc., 2021, 143, 20818?20827.
2. Zhenghui Kang, # Yongheng Wang, # Dan Zhang, Ruibo Wu, Xinfang Xu*; Wenhao Hu*, Asymmetric Counter-Anion-Directed Aminomethylation: Synthesis of Chiral β-Amino Acids via Trapping of an Enol Intermediate. J. Am. Chem. Soc., 2019. 141, 1473-1478.
3. Xue Tian, Xinfang Xu, Tongfei Jing, Zhenghui Kang* and Wenhao Hu* Enantioselective Formal Carbene Insertion into C–N Bond of Aminal: Concise Access to Chiral α-Amino-β2,2-Amino Acids. Green Synthesis and Catalysis. 2021, 2, 337-344.
4. Xiangrong Liu, Xue Tian, Jiawu Huang, Yu Qian, Xinfang Xu, Zhenghui Kang*, Wenhao Hu* Enantioselective Propargylation of Oxonium Ylide with α-Propargylic-3-Indolymethanol: Access to Chiral Propargylic Indoles. Org. Lett., 2022, 24, 1027-1032.
5. Zhenghui Kang, Dan Zhang, Xinfang Xu*, Wenhao Hu*, Privilege-Structure-Oriented Three-Component Asymmetric Aminomethylation: Assembly of Chiral 3-Aminomethyl Indolones. Org. Lett., 2019, 21, 9878-9883.
6. Zhenghui Kang, Dan Zhang, Jiayi Shou, Wenhao Hu*, Enantioselective Trapping of Oxonium Ylides by 3-Hydroxyisoindolinones via a Formal SN1 Pathway for Construction of Contiguous Quaternary Stereocenters. Org. Lett., 2018, 20, 983-986.
7. Zhenghui Kang,# Dan Zhang,# Wenhao Hu*, Regio- and Diastereoselective Three-Component Reactions via Trapping of Ammonium Ylides with N-Alkylquinolinium Salts: Synthesis of Multisubstituted Tetra- and Dihydroquinoline Derivatives. Org. Lett., 2017, 19, 3783-3786.
8. Zhenghui Kang, Jiayi Shou, Dong Xing, Wenhao Hu*, Rh(II)/Ag(I)-Cocatalyzed Three-Component Reaction via SN1/SN1′-Type Trapping of Oxonium Ylide with the Nicholas Intermediate. J. Org. Chem., 2020, 85, 9850-9862.
9. Chaoqun Ao, Jingjing Huang, Xinfang Xu, Shikun Jia, Zhenghui Kang *, Wenhao Hu*，A Rh-catalyzed Three-component Reaction for the Diastereoselective Synthesis of Pyrazolone Derivatives with Contiguous Quaternary Stereocenters. Org. Bio. Chem., 2020, 18, 3466-3470.
10. Dan Zhang, Zhenghui Kang, Junwen Liu, Wenhao Hu*, Metal-Dependent Umpolung Reactivity of Carbenes Derived from Cyclopropenes. iScience, 2019, 14, 292-300.