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Name：Jiabin Zhang 张家彬 Title：Principle Investigator Education：Medicinal Chemistry Contact Number：0760-85286866 E-mail：zhangjiabin@zidd.ac.cn Address：SSIP Healthcare and Medicine Demonstration Zone, Zhongshan Tsuihang New District, Guangdong 528400
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Biography
B.S. of Pharmaceutical Engineering
College of Chemical Engineering, Sichuan University 09/2006-06/2010
M.S. of Chemical Engineering
College of biological science, Southwest Jiaotong University 09/2012-06/2015
Ph.D. Candidate of Organic Chemistry
Department of Chemistry, Georgia State University 01/2016-12/2019
Postdoc
CCRC, the University of Georgia 01/2020 to 05/2021
Principle Investigator
Zhongshan Institute for Drug Discovery 08/2021 to present
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Research Directions
Carbohydrates play important roles in biological systems and influence cancer metastasis, bacterial and viral infection, cell-cell interactions. We focus on glycobiology, glycochemistry, medicinal chemistry and chemical biology, with emphasis on automated synthesis, carbohydrate-based vaccines, glycopeptide and glycoprotein drugs.
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Achievements
Carbohydrates play important roles in biological systems and influence cancer metastasis, bacterial and viral infection, cell-cell interactions. We focus on glycobiology, glycochemistry, medicinal chemistry and chemical biology, with emphasis on automated synthesis, carbohydrate-based vaccines, glycopeptide and glycoprotein drugs.
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Publications
14. Wang, S.S.#; Zhang, J.B.#; Wei, F.Y.#; Li, W.J.; Wen, L.Q.* Facile Synthesis of Sugar Nucleotides from Common Sugars by the Cascade Conversion Strategy. J. Am. Chem. Soc. 2022, 144, 9980.
13. Zheng, Y.#; Zhang, J.B.#; Meisner, J.#; Li, W.J.; Luo, Y.W.; Wei, F.Y.; Wen, L.Q.* Cofactor‐Driven Cascade Reactions Enable the Efficient Preparation of Sugar Nucleotides. Angew. Chem. Int. Ed. 2022, 61(20), e202115696
12. Zhang, G.L.; Gadi, M.R.; Cui, X.K.; Liu, D.; Zhang, J.B.; Saikam, V.; Gibbons, C.; Wang, P.G.*; Lei Li, L.* Protecting-group-free S-glycosylation towards thioglycosides and thioglycopeptides in water Green Chem. 2020, 23(8), 2907-2912.
11. Zhu, H.J.*; Liu, D.; Tran, V.P.; Wu, Z.G.; Jiang, K.; Zhu, H.; Zhang, J.B.; Gibbons, C.; Xue, B.Z.; Shi, H.; Wang, P.G.;* N-Linked Glycosylation Prevents Deamidation of Glycopeptide and Glycoprotein ACS Chem. Biol. 2020, 15(12), 3197-3205.
10. Zeng, C.; Sun, B.; Cao, X.F.; Zhu, H.L.; Oluwadahunsi, O.; Liu, D.; Zhu, H.; Zhang, J.B.; Zhang, Q.; Zhang, G.L.; Gibbons, C.; Liu, Y.P.; Zhou, J.* Wang, P.G.* Chemical Synthesis of Homogeneous Human E-Cadherin N-Linked Glycopeptides: Stereoselective Convergent Glycosylation and Chemoselective Solid-Phase Aspartylation. Org. Lett. 2020, 22(21), 8349–8353.
9. Zhang, J. B. #; Liu, D. #; Saikam V.; Gadi, M.; Gibbons, C.; Fu X.; Song, H. L.; Yu J.; Kondengaden M.; Wang, P. G* Wen, L. Q.* Machine Driven Glycopeptide Synthesis by a peptide synthesizer. Angew. Chem. Int. Ed. 2020, 132 (45), 19997-20001.
8. Liu, D. #; Zhang, J.B. #; Zhu, H.; Wang, M.Z.; Polizzi, J.S.; Jones, T.M.; Li, L.; Gadi, R.M.; Wang, P.G.; Ma, C. *; Huang, W. * Enzymatic depolymerization of streptococcus pneumoniae type 8 polysaccharide Carbohydrate Res. 2020, 108024
7. Zu, M.H. #; Song, H.L. #; Zhang, J.B. #; Chen, Q.B.; Deng, S.Q.; Canup, SB. B.; Yi, Y.; Xiao, B. * Lycium barbarum lipid-based edible nanoparticles protect against experimental colitis. Colloids and Surfaces B: Biointerfaces 2020, 187, 110747
6. Zhang, J. B.#; Chen, C. C.#, Gibbons, C.; Gadi, M. R.; Guo,Y. X., Wang, S. S., Liu, D., Wen, L. Q.* Wang, P. G.* Machine Driven Enzymatic Oligosaccharide Synthesis by a peptide synthesizer. Angew. Chem. Int. Ed. 2018, 57, 16638-16642.
5. Wen, L. Q. #*; Edmunds, G. #; Gibbons, C. #; Zhang, J. B. #; Gadi, M. R.; Zhu, H. L.; Fang, J. Q.; Liu, X. W.; Kong, Y.; Wang, P. G.* Toward Automated Enzymatic Synthesis of Oligosaccharides. 2018, Chem. Rev. 2018, 118(17), 8151-8187.
4. Zhang, J. B.; Liu, X. R; Deng, T. M; Yao, P; Song, H. L; Zhou, S. B; Yan, W. L.* Development of drug loaded nanoparticles binding to hydroxyapatite based on a bisphosphonate modified nonionic surfactant. Journal of Nanomaterials 2015, 16 (1), 145
3. Wang, J. J; Li, S. S; Zang, L. L; Zhu, H. L; Guo, J. S; Zhang, J. B; Wen, L. Q; Chen, Y; Li, Y. H; Chen, X; Wang, P. G;* Li, J.* Production of glycopeptide derivatives to explore the substrate specificity of human OGA towards sugar moiety. Frontiers in chemistry 2018, 6, 646
2. Wen, L. Q; Gadi, M. R; Zheng, Y; Gibbons, C; Kondengaden, S. M; Zhang, J. B; Wang, P. G.* Chemoenzymatic Synthesis of Unnatural Nucleotide Sugars for Enzymatic Bioorthogonal Labeling ACS Catalysis 2018, 8(8), 7659-7666.
1. Song, H. L; Zhang, J. B; Liu, X. R; Deng, T. M; Yao, P; Zhou, S. B; Yan, W. L.* Development of a bone targeted thermosensitive liposomal doxorubicin formulation based on a bisphosphonate modified non-ionic surfactant. Pharmaceutical development and technology 2016, 21(6), 680-687.