全国同城凤凰楼信息茶楼_51pcmc品茶2024官网_全国兼职凤凰楼信息

Biography

Education:
2004.09 - 2010.11, University of Toronto, The Hospital for Sick Children, Ph.D.
2002.09 - 2004.03, Manchester University, M.Sc.
1998.09 - 2002.07, Nanjing University, B.Sc.Work
Experience:
2020.08 - Present  Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, CAS; Professor
2018.04 - 2020.07  Shanghai Jiao Tong University School of Medicine, Shanghai Mental Health Center; Professor
2011.01 - 2018.03  Southeast University, Associate Professor

Research Directions

1. Immunoneuropsychiatry

2. Development of biopharmaceuticals for CNS disorders

Achievements

1. Systematically investigated molecular mechanisms underlying neural plasticity.
2. Investigated immunological mechanisms of neuropsychiatric disorders.

Publications

Selected publication:

1. Xu Z^#, Zhang X^#, Chang H^#, Kong Y, Ni Y, Ran Liu, Zhang X, Hu Y, Yang Z, Hou M, Mao R, Liu WT, Du Y, Yu S, Wang Z, Ji M*, Zhou Z*.  Rescue of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal Treg cells. Nature Neuroscience. 2021 Jun;24(6):818-830.

2. Mao R^#, Zhang X^#, Kong Y, Wu S, Huo HQ, Kong Y, Wang Z, Liu Y*, Jia Z*, Zhou Z*.  Transcriptome regulation by oncogenic ALK pathway in mammalian cortical development revealed by single-cell RNA sequencing. Cerebral Cortex. 2021 Jul 5;31(8):3911-3924.

3. Zhou Z*^#, He G^#, Zhang X, Lv X, Zhang X, Liu A, Xia S, Xie H, Dang R, Han L, Qi J, Meng Y, Yu S, Xie W, Jia Z. NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms. Cell Reports. 2021 Aug 17;36(7):109515.

4. Zhang X*, Kong Y, He G, Zhou Z*.  Neonatal exposure to ketamine disrupts developmental synapse unsilencing and predisposes adult mice for stressor-evoked anxiety. Neuropharmacology. 2020 Dec 1;180:108300.

5. Zhou Z^#, Liu A^#, Xia S^#, Leung C^#, Qi J, Meng Y, Xie W, Park P, Collingridge G*, and Jia Z*.  The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning. Nature Neuroscience. 2018 Jan;21(1):50-62.

6. Yang X^#, He G^#, Zhang X, Chen L, Kong Y, Xie W, Jia Z, Liu WT*, Zhou Z*. Transient inhibition of LIMKs significantly attenuated central sensitization and delayed the development of chronic pain. Neuropharmacology. 2017 Oct;125:284-294.

7. He G^#, Yang X^#, Wang G, Qi J, Mao R, Wu Z, Zhou Z*. Cdk7 is required for activity-dependent neuronal gene expression, long-lasting synaptic plasticity and long-term memory. Frontiers in Molecular Neuroscience. 2017 Nov 7;10:365.

8. Xia S^#, Zhou Z^#, Leung C, Zhu Y, Pan X, Qi J, Morena M, Hill MN*, Xie W*, Jia Z*. p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus. eLife. 2016 Jun 14;5.

9. Liu A^#, Zhou Z^#, Dang R, Zhu Y, Qi J, He G, Leung C, Pak D, Jia Z*, Xie W*. Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization. Journal of Cell Biology. 2016 Feb 15; 212(4):449-63.

10. Li Y^#, Zhou Z^#, Zhang X, Tong H, Li P, Zhang ZC, Jia Z, Xie W*, Han J*. Drosophila neuroligin 4 regulates sleep through modulating GABA transmission. The Journal of Neuroscience. 2013, 33(39):15545-54

11. Zhou Z, Hu J, Passafaro M, Xie W, Jia Z*. GluA2 (GluA2) regulates metabotropic glutamate receptor-dependent long-term depression through N-cadherin-dependent and cofilin-mediated actin reorganization. The Journal of Neuroscience. 2011, 31(3), 819-833