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1999年获得沈阳药科大学理学博士学位。毕业后留校任教，主要从事药代动力学相关的新技术和新方法研究及教学，2004年晋升为教授。2005年，加入中国科学院上海药物研究所，任研究员和课题组长。2020年，任中山药创院研究员、课题组长。

药物代谢新途径化学和生物学基础研究；基于代谢/转运机制药物相互作用研究；创新药物ADME评价。

近年来在特殊官能团代谢生物化学基础研究和药动学新技术、新方法等研究中，取得了系列研究成果，阐明了二氢吡啶酮环氧化开环机制、吗啉环立体选择性的葡萄糖醛酸代谢机制、DPPs酶介导氰基水解代谢机制等；开展了肝/肾功能不全患者药动学研究，揭示了内源性尿毒素的蓄积是导致摄取转运体OAT底物在肾功能不全患者血浆暴露量增加的原因以及肝首过代谢药物在肝功能不全患者药动学特点；负责或参与完成了我国近20%创新药物的临床前或临床ADME评价，其中已有9种批准上市，100多种批准临床试验。研究组先后承担国家自然科学基金项目7项、上海市科研项目2项，并在Drug Metab Dispos、Brit J Pharmacol、J Med Chem和Chem Res Toxicol等国际专业期刊发表SCI论文160多篇。

1.Zhou L, Pang XY, Hou XY, Liu L, Guo ZT, Chen XY*. Increased Aldehyde Oxidase Activity of Human and Rat Caused by Nimesulide. Acta Pharmacologica Sinica, 2020, https://doi.org/10.1038/s41401-019-0336-3 .

2.Tang CZ, Li L, Ma XF, Wang J, Chen B, Dai XJ, Zhang YF, Chen XY*. Qualitative and quantitative determination of anaprazole and its major metabolites in human plasma. Journal of Pharmaceutical and Biomedical Analysis, 2020, 183: https://doi.org/10.1016/j.jpba.2020.113146

3.Kong FD, Pang XY, Zhao JH, Deng P, Zheng MY, Zhong D, Chen XY*. Hydrolytic metabolism of cyanopyrrolidine DPP-4 inhibitors mediated by dipeptidyl peptidases. Drug Metabolism and Disposition, 2019, 47: 238-248

4.Tang CZ, Chen ZQ, Dai XJ, Zhu WL, Zhong DF and Chen XY*. Mechanism of Reductive Metabolism and Chiral Inversion of Proton Pump Inhibitors. Drug Metabolism and Disposition, 2019, 47: 657–664.

5.Li XL, Sun JC, Guo ZT, Zhong DF, Chen XY*, Interplay between Carboxylesterase 2 and Intestine Transporters Limits the Bioavailability of Allisartan, a prodrug of Exp3174 for Hypertension Treatment in Humans. Drug Metabolism and Disposition, 2019, 47: 843–853

6.Li JL, Li W, Dai XJ, Zhong DF, Ding YP, Chen XY*. Bioequivalence of paclitaxel protein-bound particles in patients with breast cancer: determining total and unbound paclitaxel in plasma by rapid equilibrium dialysis and liquid chromatography–tandem mass spectrometry. Drug Design, Development and Therapy, 2019, 13: 13:1739-1749

7.Hou XY, Dai XJ, Yang Y, Zhang YF, Zhong DF, Chen XY*. Simultaneous determination of imrecoxib and its two active metabolites in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography B, 2019, 1122-1123: 58-63.